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Aging: Transfusion of blood from old mice to young mice causes cellular senescence

Blood transfusion increased the number of senescent cells that accumulated with age in young mice. This suggests that cellular senescence is not just a case of wear and tear.


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August 5, 2022

Transfusion of old mouse blood into young rodents can cause the latter to age

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Transfusion of young mice with blood from older rodents immediately triggers agingThis suggests that cellular senescence is not just a case of exhaustion.

It has been hypothesized for many years that surgically connecting old mice and young rodents triggers blood migration that prevents aging in old mice. While this has benefits for older mice, the effect on young donor rodents was less clear.

you can learn more about Irina Convoy At the University of California, Berkeley, her colleagues transfused blood between young and old mice. Three-month-old animals were bled from animals approaching two years of age.

After 2 weeks, the number of senescent cells increased in young mice. These cells, the liver, kidney, and muscle cells, are damaged and stop dividing, but do not die. These cells accumulate as a normal part of aging, and a person’s life span begins after a few years.

Strength tests also revealed that young mice became weaker after receiving the blood of older rodents.

Overall, the results suggest that senescent cells can be induced in young animals other than chronological aging.

“Cellular senescence is just one part of the aging process,” says Conboy. “This breaks new ground and helps explain why we need senoritics. [drugs that clear senescent cells in the body] Clinical trials so far have not been as successful as people had hoped. ”

The experiment could also help researchers trying to tackle the health issues of aging.

“This is a very exciting study that highlights the potential of anti-aging treatments. Roman Bauer at the University of Surrey, England.

Bauer highlights the previous method Study shows removing senescent cells from mice rejuvenates bloodReferring to Berkeley’s research, he said:

Journal reference: natural metabolism, DOIs: https://doi.org/10.1038/s42255-022-00609-6

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Aging: Transfusion of blood from old mice to young mice causes cellular senescence

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