Chemicals derived from grape seeds selectively destroy worn-out cells in mice, allowing them to live 9% longer than untreated cells.
December 6, 2021
Chemicals isolated from grape seed extract extend the lifespan of aged mice by 9 percent by clearing old and worn cells. Treatment also appears to make mice physically healthy and reduce the size of tumors when used in combination with chemotherapy to treat cancer.
This finding reinforces the case of future anti-aging therapies targeting senescent cells, that is, senescent cells that lose their ability to replicate and instead release substances that cause inflammation.
Senescent cells increase in number as we grow older and are associated with a variety of age-related conditions such as cardiovascular disease, type 2 diabetes, and osteoporosis.
To find substances that can destroy these cells, Qixia Xu At the Chinese University of Science in Shanghai, colleagues screened a library of chemicals related to aging for their effects on senescent cells. A team study found a chemical in grape seeds called procyanidins C1 (PCC1).
At low concentrations, PCC1 appeared to prevent senescent cells in the dish from producing inflammatory substances. At high concentrations, the chemical killed the cells, but the young cells remained intact.
To test its efficacy in live animals, the team injected 171 2-year-old mice (equivalent to about 70 at human age) with either PCC1 or a control solution twice a week. bottom. On average, PCC1 extended mouse lifespan by 9%.
This chemical also seems to improve the physical fitness of young mice. Animals younger than 2 years were injected with either control solution or PCC1 every 2 weeks for 4 months, followed by various physical tests. The treated mice had significantly faster maximum walking speed, stronger grip strength, and better endurance when running on a treadmill than mice given the control solution.
Chemotherapy is known to accelerate the aging of cells in tumors. To investigate whether PCC1 can kill these aged tumor cells and increase the effects of chemotherapy, the team used them to treat cancers such as breast cancer, non-Hodgkin’s lymphoma, and acute myeloid leukemia. I tried chemotherapy with the drug mitoxantrone.
The team tested this combination therapy in mice transplanted with cells from human prostate tumors. Treatment of mice with both PCC1 and mitoxantrone reduced the tumor by about 75%, but chemotherapy alone reduced the tumor by an average of 44%.
The fact that the chemicals don’t seem to affect healthy cells suggests that it could be a “promising anti-aging treatment,” he says. Dorian Ziegler At the University of Lausanne, Switzerland. Future studies need to investigate whether PCC1 has a similar effect on people, he adds.
Journal reference: Natural metabolism, DOI: 10.1038 / s42255-021-00491-8
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Anti-Aging: Mice treated with chemicals from grape seed extract live 9% longer and are physically healthier.
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