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Anti-aging technology makes skin cells 30 years younger

Skin cells reverse their development but are still exposed to molecules that retain their function, creating a type of stem cell that retains its original function in the body.


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April 8, 2022

Fluorescence micrograph of fibroblasts from human skin

VSHYUKOVA / SCIENCE PHOTO LIBRARY

Researchers have developed a way to reverse the body clock of skin cells 30 years ago, creating stem cells from mature cells that can be used to treat future skin conditions.

In 2007, Shinya Yamanaka Kyoto University in Japan has developed a technology that can convert adult skin cells into stem cells by inserting four special molecules called “Yamanaka factor” that reverse the development of cells.It takes about 50 days of exposure to these molecules for normal cells to be reprogrammed into what is known as Induced pluripotent stem cells (IPS cells).

“When you convert a cell to an iPSC, you lose the original cell type and its function,” he said. Dill Git Gil At the Babraham Institute in Cambridge, England.

Gil and his colleagues have devised a technique that uses the Yamanaka factor to rejuvenate skin cells without losing their previous function.

Researchers collected skin cell samples from three human donors with an average age of about 50 years and exposed them to Yamanaka factor for only 13 days to partially anti-age the cells. After that, Yamanaka factor was removed and the cells were grown.

As we grow older, our DNA is tagged with chemicals, so tracking these markers helps determine how old our body is. This is known as the epigenetic clock.Over time, some of our genes are turned on or off, and their collections Transcriptome..

Gil and his team found that the epigenetic clock and transcriptome profile of partially reprogrammed cells matched the profile of skin cells belonging to people 30 years younger.

Rejuvenated cells also acted like young cells, producing more cells collagen Than the one that did not undergo reprogramming. And when placed on an artificial wound, the reprogrammed cells moved to close the gap much faster than the old one.

“For young people, if you cut the cut yourself, it takes time to heal the wound, but it takes me time to heal,” says the team members. Wolf-like, At the Babraham Institute. “It’s very exciting. As well as reading young molecules, cells act like young cells.”

A significant advance in this study is the ability to significantly activate cells without altering their identity or function, says Reik. “In previous studies, it turned out to be stem cells, which is not necessary for treatment.”

This technique may one day help treat skin conditions such as burns and ulcers. Since cells are their own cells, there is an additional bonus that cells are not rejected by the individual’s body, Gil says.

“So far, this technique has only been tested on skin cells. I’m looking forward to translating it into other cell types,” says Gill.

Journal reference: eLife, DOI: 10.7554 / eLife.71624

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Anti-aging technology makes skin cells 30 years younger

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