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Are COVID boosters needed? FDA experts among group opposing US plan – Portland, Oregon

Portland, Oregon 2021-09-13 16:10:38 –

File – File on Sunday, July 11, 2021 In the photo, a doctor fills a syringe with Johnson & Johnson COVID-19 vaccine at a vaccination center. (AP Photo / Rahmat Gul, file)

The average person does not yet need a COVID-19 booster, an international group of scientists-including two top US regulators-written in a scientific journal on Monday.

Experts reviewed studies on vaccine performance and concluded that shots worked well, especially for serious illnesses, despite the highly contagious delta mutant.

At this stage of the pandemic, “even in highly vaccinated populations, unvaccinated remains the main driver of infection.” They made a conclusion..

An opinion piece published in The Lancet presents a fierce scientific debate about who needs booster doses and when and when the United States and other countries are working on decisions.

President Joe Biden promised to “follow science” after political interference in the Trump administration’s coronavirus reaction was revealed. However, the review raises the question of whether his administration is moving faster than the experts.

The authors include Drs, two major vaccine reviewers at the Food and Drug Administration. Phil Krause and Marion Gruber recently announced that they will resign this fall. Among the other 16 authors, in addition to leading vaccine researchers in the United States, United Kingdom, France, South Africa and India, World Health already seeks a booster moratorium until poor countries receive better vaccinations. There are institutional scientists.

In the United States, the White House began planning boosters later this month if both the FDA and the US Centers for Disease Control and Prevention agree. FDA advisers weigh evidence that additional Pfizer was shot at a major public meeting on Friday.

Larry Gostin of Georgetown University said in a discussion about whether most Americans really need boosters and whether the White House is ahead of scientists, the paper “throws petrol into the fire.” Said.

“Making scientific presentations before public health agencies act has always been a fundamental mistake in the process, and that’s exactly what happened here,” said Gostyn, a lawyer and public health expert. I did.

The FDA did not respond to a request for comment on Monday morning.

The United States has already provided additional doses of the Pfizer or Moderna vaccine to people with significantly weakened immune systems.

For the general public, hoping to prevent mild “breakthrough” infections, perhaps among fully vaccinated people, even though the vaccine still provides high protection against serious illness. There is a heated debate about whether to give booster immunity.

Last week, CDC director Rochelle Walensky said that a surge in deltas would make unvaccinated people 4.5 times more likely to be hospitalized, more than 10 times more likely to be hospitalized, and 11 times more likely to die if they were unvaccinated. He said the new data showed. Still, government scientists are also considering hints that protection is weakening among older people who were vaccinated early last winter.

The author of the commentary on Monday reported that he has been reviewing global studies of vaccines, primarily in the United States and Europe, since the Delta began to surge. The team concluded that “none of these studies provide credible evidence that protection against serious illness is significantly reduced.”

As the body builds a layer of immunity, a gradual decrease in antibody levels does not necessarily mean a decrease in overall efficacy. “Decrease in vaccine efficacy for mild disease does not necessarily mean for severe disease. It does not predict a decrease in effectiveness (usually higher). “

The more the virus spreads, the more chances it has to evolve into a strain that can escape the current vaccine. Lancet reviewers may benefit significantly by creating a booster dose that is more consistent with the circulating mutants than by boosting the original vaccine so that the influenza vaccine is updated regularly. It suggests that there is sex.

“Now we have the opportunity to study variant-based boosters before they become widely needed,” scientists write.

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