According to a study by the European Medicines Agency (EMA) of the European Union, the COVID-19 vaccine produced by AstraZeneca and the University of Oxford can cause abnormal blood clots with abnormally low platelets (small blood cells involved in clotting). ..
These rare blood Blood clots and decreased platelet count should be listed as possible side effects vaccine, EMA Executive Director Emer Cooke, Said at a press conference April 7th, according to Science Magazine correspondent Kai Kupferschmidt. People who received the shot should pay attention to these potential side effects, especially within the first two weeks of vaccination, she said. According to CNN..
Despite the risk of blood clots, the study “confirmed that the benefits of the AstraZeneca vaccine in the prevention of COVID-19 outweigh the risk of side effects overall,” Cook said.
However, the EMA does not yet have data to say that it applies to groups of all, Sabine Straus, chair of the Pharmacovigilance Risk Assessment Committee (PRAC), said at a news conference. When asked if the risk of a vaccine could actually outweigh the benefits of a particular age group, Straus said, “At this point, it’s very difficult to answer for clinical trials … We don’t have all age group data available. ” To CNN.
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In that study, PRAC thoroughly reviewed 62 cases of cerebral venous sinus thrombosis. There, blood clots form in the venous channels that drain blood. brain, CNN reported. They also analyzed 24 cases of visceral vein thrombosis. In this thrombosis, blood clots form in one or more veins in the abdomen. liver And spleen..
These cases were reported in the EU’s Pharmacovigilance database, killing 18 people, Strauss said. Also, as of April 4, “34 million people have been vaccinated in the European Economic Area and the United Kingdom” (European Economic Area includes members of the European Union, Iceland, Liechtenstein and Norway. Will be).
Although it was difficult to assess the overall frequency of the condition, Strauss estimates that “about 1 in 100,000” people vaccinated against AstraZeneca could be affected. I said there is. She said the percentage of reported cases could vary depending on the goodness of the reporting system in a particular country and the diagnosis and extent of the case, so it is necessary to confirm the exact percentage.
JCVI, the UK Vaccine Advisory Group, recommends providing alternative vaccines to people aged 18-29. This figure (UK risk) shows why. Note the importance of balancing harm. pic.twitter.com/Kl2GURyqSgApril 7, 2021
The Advisory Committee on Immunization and Implementation (ACIP) in the United States is also monitoring blood clots associated with the mRNA COVID-19 vaccine developed by. Modana And Pfizer — Two of the three COVID-19 vaccines approved for emergency use in the United States along with the Johnson & Johnson vaccine. With more than 50 million injections in the arm, the rate of blood clots in US vaccinated people does not appear to be higher than in the general population. According to a report released on March 1st.. The data suggest that these rare side effects appear to be uniquely associated with the AstraZeneca vaccine rather than the mRNA-based vaccine.
According to Cook, PRAC was unable to clearly identify specific risk factors that are likely to cause rare coagulopathy that may be associated with the AstraZeneca vaccine, such as age, gender, and history of blood clots. .. However, according to CNN, so far most of the reported cases have occurred in women under the age of 60 and within two weeks of vaccination.
More research will be needed to see if side effects are really more common in women, or if other risk factors are working.
Similarly, “currently available data did not identify a clear cause for these complications,” Straus said. “A plausible explanation was given,” she said.
For example, vaccines can provoke an immune response similar to “heparin-induced thrombocytopenia” (HIT). Immune system According to Strauss, it usually attacks important molecules and proteins that regulate blood clotting.
Specifically, these autoantibodies target a complex composed of heparin (a molecule that thins blood) and platelet factor 4 (a protein secreted by platelets that weakens the effects of heparin). Graduate School of Medicine Journal.. When an antibody latches on this complex, its physical structure changes, making it appear “foreign” to the immune system, and the immune system produces new antibodies that target it. The antibody-coated complex is then connected to platelet receptors, pushing cells into the hyperdrive and creating blood clots.
Researchers in Germany and Norway have reported cases such as HIT in patients vaccinated with AstraZeneca injections, and have also identified antibodies that may cause the reaction. NPR reports..
Alternatively, some scientists believe that vaccines can ruin the so-called complement system, a part of the immune system that helps remove pathogens and infected cells from the body. Science magazine reported..Peplomer, protruding structure Coronavirus, Can bind to the inner layers of blood vessels and activate this complement system. In some people, the complement system can attack the blood vessels themselves, causing blood clots.
Science has reported that something similar could have happened in response to the AstraZeneca vaccine, which helps cells in the body build spike proteins, but that’s just a theory so far.
“As time goes on, we can expect new information and new recommendations,” Cook said at a news conference.
In light of new data, the UK has announced that it will offer alternative vaccine options to adults under the age of 30. The New York Times reported.. Similarly, Germany stopped distributing the AstraZeneca vaccine to people under the age of 60 last week. According to CNN..
Originally published in Live Science.
AstraZeneca COVID-19 vaccine causes very rare blood clots, EU regulators say
Source link AstraZeneca COVID-19 vaccine causes very rare blood clots, EU regulators say