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AstraZeneca shots have a slightly higher risk of bleeding problems, a new study says

People who received the Oxford-AstraZeneca Covid vaccine had a slightly increased risk of bleeding disorders and other rare blood problems, the researchers reported Wednesday.

The results of a study of 2.53 million adults in Scotland who were first given either the AstraZeneca vaccine or the Pfizer Bio-N-Tech vaccine are as follows: It was published in the journal Nature Medicine. About 1.7 million shots were AstraZeneca vaccines.

This study did not show an increased risk of blood dyscrasia with the Pfizer-BioNTech vaccine.

The AstraZeneca vaccine is not licensed for use in the United States, but is approved by the European Medicines Agency, the highest drug regulator in the European Union, and many countries outside the block. However, reports of rare coagulopathy and bleeding disorders in young adults are partly fatal, limiting vaccine use to the elderly in many countries and completely discontinuing the vaccine in some countries. did.

A new study found that the AstraZeneca vaccine was associated with a slight increase in the risk of a disorder called immune thrombocytopenic purpura (ITP). The risk was estimated to be 1.13 per 100,000 initial doses up to 27 days after vaccination. That estimate adds to the typical incidence in the United Kingdom before the vaccine was used, estimated at 6-9 cases per 100,000 people.

The condition was treatable and none of the vaccinated cases was fatal, the researchers said.They emphasized that the benefits of vaccines far outweigh the small risks and pointed out that Covid itself is far more likely to cause ITP than vaccines.

However, researchers also write that although the risk of AstraZeneca vaccine is small, “if supply permits, an alternative vaccine for individuals at low Covid-19 risk may be justified.”

It’s not surprising that ITP was found in several vaccinated people, researchers said, with measles, mumps, rubella vaccination, and hepatitis B and influenza vaccinations at a slight risk. He said it had increased.

In a commentary published in this study, hematological disorders experts said that diagnosing ITP can be difficult and that further analysis is needed for possible associations. However, they write, “Nevertheless, the risk of ITP induced by vaccination at the proposed rate seems to be much lower than the many risks associated with Covid-19 itself.” ..

A study in Scotland also found a very slight increase in the risk of arterial thrombosis and bleeding that may be associated with the AstraZeneca vaccine. However, the researchers said there were not enough data to conclude that the vaccine was associated with a rare type of thrombosis in the brain called cerebral vein sinus thrombosis. Earlier this year, reports of these strokes suspended or restricted the use of the vaccine in some countries.

Researchers said the association with cerebral thrombosis could not be ruled out, but there were not enough cases to analyze.

Professor Aziz Sheikh, a senior author of research at the University of Edinburgh, said at a news conference that cerebral thrombosis is “as rare as chicken teeth.”

Similar concerns have been raised about rare disorders associated with cerebral thrombosis and bleeding, primarily in young women, related to the Johnson & Johnson vaccine approved in the United States and other countries. With six US cases, including one death, federal health officials ordered the suspension of vaccine use in April.The· The suspension was lifted after 10 days, And the vaccine has been revived with a label to warn consumers about the risk of blood clots and the availability of other vaccines. Later, a few more cases were identified and advised doctors to avoid using the standard treatment heparin, as these cases can exacerbate the condition.

The risk of coagulation Denmark declines Use either AstraZeneca or Johnson & Johnson Vaccine.

Both AstraZeneca and Johnson & Johnson vaccines use so-called viral vectors to carry the genetic material to the recipient’s cells. Some researchers suggest that the vector can cause rare blood disorders. It is unknown if there is a connection.

The authors of the Scottish study said it was unclear if their findings on the AstraZeneca vaccine would have any effect on the Johnson & Johnson vaccines they had not studied.

AstraZeneca shots have a slightly higher risk of bleeding problems, a new study says

Source link AstraZeneca shots have a slightly higher risk of bleeding problems, a new study says

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