How do different parts of the body communicate? Scientists at St. Jude are studying how signals sent by skeletal muscle affect the brain.
The team studied state-of-the-art brain cell models called fruit flies and organoids. They focused on the signals that muscles send when stressed. Researchers have discovered that stress signals depend on an enzyme called amylase amylase and its product, the disaccharide maltose.
Scientists have shown that mimicking stress signals can protect the brain and retina from aging. The signal works by preventing the accumulation of accidentally folded protein aggregates. Research suggests that regulating this signaling may help combat neurodegenerative conditions such as age-related dementia and Alzheimer’s disease.
We have found that muscle-induced stress responses can not only affect muscles, but also promote protein quality control in distant tissues such as the brain and retina.This stress response actually protected those tissues during aging.. “
Dr. Fabio Demontis, Developmental Neurobiology, St. Jude Children’s Research Hospital
Cell metabolism We have released a report on this work.
By mimicking stress signals, you can protect your brain and retina from aging
Source link By mimicking stress signals, you can protect your brain and retina from aging