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Cancer: A map of proteins in tumor cells identifies therapeutic targets


3D illustration of proteins containing lymphocytes and cancer cells

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The first map of how proteins interact in cancer highlights previously overlooked mutations that may be the target of treatment.

Trey Ideker and his colleagues at the University of California, San Diego said that dozens of common cancer proteins are breast cancer. Head and neck cancer..

“Oncogenes don’t work alone,” says Ideker. “It’s the same as the parts of other machines. Each one influences each other.”

Protein interaction maps include cataloging all the different ways proteins interact in a biological system. In this case, the team picks 61 proteins that are commonly mutated in two cancers and how they interact with each other and with hundreds of other proteins in cancer tumors. Decided.

“We are looking for a community of proteins that are being pressured to mutate during cancer,” says Ideker.

For head and neck cancer, the team discovered 771 protein interactions involving about 650 proteins, and 84% of the interactions had never been reported. If these interactions are important for tumor growth, future tumor drugs that target and destroy them can slow cancer growth.

Meanwhile, looking at the overall data, the team discovered a mutation in the protein collagen that was overlooked in previous studies.

“This is a big step forward in research,” says Ideker. “There has been anecdotes about finding cancer mutations this way, but no one has systematically shown this.”

Ideker hopes that this method will be used in other cancers and that others will participate in the quest to map more protein interactions in cancer. Not only does this help scientists find new drugs, but it also helps scientists find new cancer biomarkers. This helps doctors devise more personalized treatments.

“By identifying which proteins often work together in a particular cancer and helping to understand how mutations affect such protein interactions, this study studies the development and progression of cancer. Helps to achieve a better understanding of Chris Bacal At the Cancer Institute in the United Kingdom.

But he states that the main value of this study is to emphasize how protein interactions are best mapped to cancer first, as researchers have only examined a small number of proteins.

“More work is needed,” he says.

Journal reference: Chemistry, DOI: 10.1126 / science.abf2911

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Cancer: A map of proteins in tumor cells identifies therapeutic targets

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