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CDC panel grapples with who needs a COVID-19 booster shot – Honolulu, Hawaii

Honolulu, Hawaii 2021-09-22 17:30:00 –

A leading advisory board at the Centers for Disease Control and Prevention today addressed the question of which Americans should get. COVID-19 (New Coronavirus Infection) Booster shot. Some members are wondering if the decision should be postponed for a month in the hope of more evidence.

Doubt and uncertainty came to light when the Biden administration outlined its full plan a month ago, whether to dispense additional doses to enhance American protection against the coronavirus. The deployment of boosters again suggested that it might be more scientifically complex than it might be. Deployment was supposed to start this week.

Much of the discussion at the CDC Immunization Implementation Advisory Board meeting focused on the potential of reduced booster programs for the elderly or perhaps healthcare professionals. But still, some experts said the data on whether boosters are really needed, who should get them, and when to get them is not clear.

“What’s the downside?” Asked Dr. Sarah Long of Drexel University, who just waited a month in anticipation of more information.

The two-day meeting was scheduled to resume on Thursday, but it wasn’t immediately clear if it would happen.

The meeting took place a few days after another advisory group, which serves the Food and Drug Administration, overwhelmingly rejected the large-scale White House plan to distribute third shots to almost everyone. I did. Instead, the panel approved a booster dose of Pfizer vaccine only for the elderly and those at high risk for the virus.

The COVID-19 vaccine continues to provide strong protection against severe illness, hospitalization and death, but immunity to mild infections appears to be diminished months after vaccination.

“In the United States, in September 2021, I would like to emphasize that COVID-19 deaths can be prevented with vaccines in the primary series of any of the three vaccines available,” said a member of the CDC Advisory Board. Researcher Dr. Matthew Daly said. In Kaiser Permanente, Colorado.

Dr. Helen Cape Talbot of Vanderbilt University, no matter how good the COVID-19 vaccine is, the general public should understand that for mild infections, “it is unlikely that everything can be prevented.”

Some panelists said another concern was the general confusion that could arise if boosting immunization was recommended only to specific recipients of the Pfizer vaccine. It can leave you wondering what to do with people vaccinated with Moderna or Johnson & Johnson shots.

The conference was dedicated to Pfizer booster shots only. Moderna’s application for the third dose is not very advanced in the process. And major US studies on whether booster dose mixing and matching are safe and effective are not complete.

Many experts are worried about the need for boosters because they believe that the COVID-19 vaccine is working as expected, even in the face of the epidemic of highly contagious delta variants. Virus blocking antibodies are usually highest immediately after vaccination and then decline in the months that follow.

“It doesn’t matter if the antibody is weakened. We care about the minimum protection needed,” Long said.

Still, no one knows the threshold of antibody levels that suddenly raises someone’s risk of infection. Still, the body has backup protection.

Even antibody production and their backup defenses are not very well formed in the elderly. However, it is not possible to pinpoint the age at which it matters, CDC microbiologist Natalie Thornberg told the Commission.

Ultimately, the Commission must decide who is considered to be at high enough risk for additional doses.

CDC officials have released data from several US studies and shots early in the vaccination campaign with some groups, especially people over the age of 65.

There is also a hint that at age 75, protection against hospitalization may be somewhat reduced. However, the CDC said there is little information about weakened immunity in young people with chronic medical problems.

Some panelists also wondered about boosters for healthcare workers who couldn’t come to work even with mild infections.

“There aren’t enough healthcare workers to take care of unvaccinated people. They just keep coming,” Talbot said.

Another question was whether to give a booster months after the second shot. Scientists talked for about 6 or 8 months.

When it comes to booster safety, serious side effects are extremely rare with the first two doses. Pfizer has received 2.8 million boosters in Israel, primarily for people over the age of 60, with fewer annoying side effects such as pain and fever on the third dose than previous shots. I pointed out that. There was one report of heart inflammation, a rare risk sometimes seen in young men.

In the United States, more than 24,000 volunteers for the CDC vaccine safety tracking system reported receiving additional doses, as well as no warning signs.



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