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COVID-19 can cause recurrent episodes of Guillain-Barré syndrome, case studies show

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Caused by the pathogen Coronavirus Disease 2019 (COVID-19) is a new disease that scientists are competing for a better understanding. It hopes to develop therapeutic and prophylactic approaches that will help save lives and control the spread of the virus.

A team of researchers at Robert Wood Johnson Medical College at Rutgers University in the United States investigated a case in which a man experienced a recurrent episode of Guillain-Barré syndrome after being infected with SARS-CoV-2.

Their work is available in the latest issue of the journal. Pathogen (November 2020)..

Guillain-Barré Syndrome (GBS) and COVID-19

Guillain-Barré Syndrome (GBS) is a rare disease in which the body’s immune system attacks nerves. Common signs and symptoms of this condition include weakness and tingling in the extremities. When the condition worsens, the sensations spread rapidly and eventually the whole body becomes paralyzed.

Recent studies have shown that COVID-19 is associated with a wide range of immunoneuropathy, including GBS. It is also associated with exacerbation of chronic inflammatory demyelinating polyradiculoneuritis (CIDP).

Recurrent GBS has two or more episode-to-episode intervals of less than 4 months, or more than 2 months if the patient shows complete or near-complete recovery. Defined as a GBS episode.

Patient case

The case study highlights the case of a man who suffered from recurrent GBS over the years. His symptoms were exacerbated when he experienced a recent seizure with COVID-19.

The patient, a 43-year-old man, had a car accident and came to the emergency department of Rutgers Robert Wood Johnson University Hospital (RWJUH) with numbness and tingling in both upper limbs. He also had patchy sensory loss on his upper limbs.

The patient suffered other injuries to the cervical and lumbosacral vertebrae and was diagnosed with a herniated disc. Four years later, the patient developed an acute illness with coughing, fever, and ageusia, and the food tasted like clay. He was finally diagnosed with influenza A.

However, three days after the initial diagnosis, he developed numbness in both his arms and legs. Then it went to his trunk. He was diagnosed with GBS, multiple sclerosis, and Lyme disease, blunting speech and facial weakness. He recovered completely within a week without any treatment.

He had two more similar episodes after the virus infection. In April 2020, a 54-year-old patient came to the emergency room complaining of progressive dysphagia. He had a fever for three days, after which his arms, legs and face were weakened.

Doctors performed tests to determine the cause of his fever episode and found that the reverse transcription polymerase chain reaction (RT-PCR) test for COVID-19 was positive. Doctors treated patients with rGBS secondary to COVID-19.

A timeline of events related to recurrent neurological symptoms. This figure highlights the preceding viral infection if the interval between flu-like symptoms and neurological symptoms and the decrease in the interval between flares are known.

A timeline of events related to recurrent neurological symptoms. This figure highlights the preceding viral infection if the interval between flu-like symptoms and neurological symptoms and the decrease in the interval between flares are known.

The patient described GBS symptoms with his latest seizures caused by COVID-19 and showed worse symptoms.

Researchers said this was the first case of recurrent GBS associated with COVID-19, indicating that its severity was enhanced compared to previous episodes.

“Increased studies may indicate that the proportion of GBS in COVID-19 patients is higher than the background GBS incidence. By studying rGBS patients, a better understanding of the pathophysiology of COVID-19 And it can be compared to the precursors of other viruses against GBS, “the researchers wrote in the paper.

“Patients with a history of inflammatory demyelinating polyradiculoneuritis developing COVID-19 are advised to carefully observe their neurological symptoms over the next few days to weeks,” they add. I did.

Previous COVID-19 pandemic

COVID-19 is a new viral disease that is causing havoc around the world. To date, more than 60.57 million people have been infected. In addition, the virus has killed more than 1.42 million people. Many countries, including the United States, India, Brazil and France, are reporting a surge.

In the United States, there are more than 12.79 million confirmed cases and more than 262,000 deaths. India, Brazil and France are tracking a staggering 9.26 million, 6.16 million and 2.22 million cases.

The UK reports a surge in COVID-19 cases over the past two months. The country has more than 1.56 million cases and 57,000 deaths.

In Mexico, COVID-19 has a high mortality rate. In more than one million cases, the death toll there reached an astonishing 103,000.

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Journal reference:

COVID-19 can cause recurrent episodes of Guillain-Barré syndrome, case studies show

Source link COVID-19 can cause recurrent episodes of Guillain-Barré syndrome, case studies show

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