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Customized vaccine being tested in Boston could revolutionize cancer treatment – Pittsburgh, Pennsylvania

Pittsburgh, Pennsylvania 2021-11-04 13:27:00 –

Vaccines that could revolutionize cancer treatment are being tested in Boston. Customized vaccines are intended to help the body’s immune system target individual tumors. His wife, mother, and Boston Celtics executive Heatherwalker are participating in the clinical trial. In July, doctors found a rapidly growing tumor in her brain called glioblastoma. A rare and aggressive form of cancer is diagnosed in about 13,000 adults each year in the United States. Over 93% of patients die within 5 years, with an average survival time of approximately 15 months. Historically, when glioblastoma was diagnosed, patients were often referred to palliative care, a type of hospice situation, because treatment was ineffective. “. Dr. David Riadon, clinical director of the Center for Neuro-Oncology at the Dana-Farber Cancer Institute, said. Walker has already undergone surgery, radiation therapy and chemotherapy. When Walker recently interviewed sister station WCVB, she received exciting news about her next steps. The first dose of customized vaccine has arrived. “Oh, I’m very lucky,” she said after reading the message. “It will save my life.” Reardon and his team at MIT use tumor DNA to create a gene that can be used to create a vaccine that teaches a patient’s immune system to attack cancer cells. I’m looking for mutations and abnormal proteins. “This is somewhat similar to the flu or COVID vaccine, where people have a vaccine that sensitizes the immune system against the flu or COVID virus,” he said. “But here we are designing a vaccine that is specific to that patient’s tumor.” A formula designed for Walker may work for her, but not for others. .. The custom vaccine process is costly and labor intensive and takes 3 months to complete. Riadon considers Walker to be a good candidate for treatment. She was relatively young and the surgery succeeded in removing most of the mass in her brain. Walker expects to receive her first dose next week. Click here for more information on clinical trials.

Vaccines that could revolutionize cancer treatment are being tested in Boston. Customized vaccines are intended to help the body’s immune system target individual tumors.

Heather Walker, Wife, mother, Boston Celtics executives Clinical trial.. In July, doctors found a rapidly growing tumor in her brain called glioblastoma.

A rare and aggressive form of cancer is diagnosed in about 13,000 adults each year in the United States. Over 93% of patients die within 5 years, with an average survival time of approximately 15 months.

“Historically, when glioblastoma was diagnosed, patients were often referred to palliative care, a form of hospice situation, because treatment was ineffective,” said David, clinical director of the Center for Neuro-Oncology.・ Dr. Riadon said. Dana-Farber Cancer Institute.

Walker has already undergone surgery, radiation therapy and chemotherapy.

When Walker recently interviewed sister station WCVB, she received exciting news about her next steps. The first dose of customized vaccine has arrived.

“Oh, I’m very lucky,” she said after reading the message. “It will save my life.”

Riadon of MIT and his research team are looking for genetic mutations and abnormal proteins that can be used to create vaccines that use tumor DNA to teach the patient’s immune system to attack cancer cells.

“This is somewhat similar to the flu and COVID vaccines, and people have vaccines that sensitize the immune system against the flu and COVID viruses,” he said. “But here we are designing a vaccine that is specific to that patient’s tumor.”

A formula designed for Walker may work for her, but it doesn’t work for anyone else.

The custom vaccine process is cost and labor intensive and can take up to 3 months to complete.

Riadon considers Walker to be a good candidate for treatment. She was relatively young and the surgery succeeded in removing most of the mass in her brain.

Walker expects to receive her first dose next week.

Click for more information on clinical trials here..

Customized vaccine being tested in Boston could revolutionize cancer treatment Source link Customized vaccine being tested in Boston could revolutionize cancer treatment

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