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George Mason researchers investigating COVID-19 therapy

Wu Yun Tao, a professor of molecular microbiology, and Hakami Ramin, an associate professor of the Faculty of Systems Biology, are studying COVID-19 therapy.

Recent studies from several independent groups have shown that K18-hACE2 transgenic mice serve as a suitable animal model for studying COVID-19.

Published studies have shown that ACE2 is a human cell invading receptor for both SARS and SARS-CoV-2. The study also used K18-hACE2 mice to reproduce many of the COVID-19 findings in human patients by infection either by the intranasal (IN) route or the intraperitoneal (IP) symptomatological SARS-CoV- 2 Indicates that an infection can be established. Virus injection. Therefore, the K18-hACE2 model of SARS-CoV-2 infection reproduces many features of severe COVID-19 infection in humans and can be used as an in vivo model for testing vaccines and antivirals.

The task completed by Wu and Hakami as part of this study agreement will be used to assess the efficacy of the treatment developed by Dejia Harmony for COVID-19 using the K18-hACE2 mouse model. Following toxicity studies to ensure that there are no adverse effects on mice, researchers will test both therapeutic and prophylactic effects.

Wu and Hakami received $ 97,724 from Desia Harmony for this job. Funding will begin in November 2020 and end in November 2021.

George Mason researchers investigating COVID-19 therapy

Source link George Mason researchers investigating COVID-19 therapy

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