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Heart Research UK is funding a new project to investigate the effects of COVID-19 on blood vessels and blood pressure

The University of Glasgow project, which aims to better understand the effects of COVID-19 infection on blood vessels and blood pressure, received a £ 250,000 grant from the national charity Heart Research UK.

Image Credit: Heart Research UK

Studies show that older people, obesity, men, or people with other medical problems such as high blood pressure, heart disease, diabetes, cancer, and chronic lung disease are at increased risk of developing severe COVID-19. I know. Hypertension is a major risk factor for cardiovascular disease and is very common in more than a quarter of affected UK adults.

The virus that causes COVID-19 invades cells of the body through receptors called ACE2 in the lungs, heart, blood vessels, kidneys, liver, and intestines. ACE2 is very important for maintaining many of the body’s important processes such as blood pressure, inflammation and wound healing.

COVID-19 can also damage the walls of blood vessels, increasing the risk of blood clots. This is common in people with high blood pressure. The reason for this is still unknown. Therefore, we need to understand more about the relationship between COVID-19 and hypertension.

The study, led by Professor Sandosh Padmanavan, a professor of cardiovascular genomics and therapies, aims to answer the following:

  • High blood pressure exacerbates COVID-19 infection. If so, why.
  • COVID-19 infection exacerbates high blood pressure, and if so, why.
  • During the pandemic, monitoring and management of hypertension needs to be a higher priority.

This study examines regularly collected health records of people who visited a hospital in western Scotland between April 2020 and April 2021 or tested positive for COVID-19. This will be compared to the records of patients who visited the hospital in 2019. For another reason. They also look closely at groups of people with high blood pressure.

Professor Padmanabhan’s team will also study a group of people who have recovered from COVID-19 infection. They undergo blood pressure monitoring and heart and blood vessel health tests. These tests are repeated after 12 and 18 months to see if there have been any changes. They are compared to a group of people who do not have COVID-19.

Finally, this study looks at markers in the blood (biomarkers) with the aim of identifying markers associated with high blood pressure, cardiovascular disease, or death in COVID-19.

This study helps to better understand the association between COVID-19 infection and hypertension and improve the long-term outcome of COVID-19 survivors. The findings may also lead to recommendations for monitoring and managing blood pressure during a pandemic.

The current COVID-19 pandemic caused by the SARS-CoV-2 virus exposed unexpected cardiovascular fragility at all stages of the disease. The mechanism by which the SARS-CoV-2 virus causes infection is thought to have direct and indirect effects on the cardiovascular system, which can lead to newly developed hypertension, heart failure, and stroke, long- It represents the insidious characteristics of COVID.

The burden of hypertension as a result of the COVID-19 pandemic is unknown, but this will be a major concern in the future, especially given the magnitude of infection among adolescents. The project will inform hypertension management strategies and generate valuable evidence to reduce cardiovascular risk in COVID-19 survivors. “

Sandosh Padmanavan, Professor of Cardiovascular Genomics and Therapeutics, Heart Research UK

I am happy to be able to support the work of the professor Padmanavan and his team are conducting important research on one of the greatest medical challenges the world has ever faced. We have long known that people who already have cardiovascular disease are more likely to develop serious complications from COVID-19. We hope that this study will explain why this is the case and help reduce the risk of this vulnerable group and ultimately save more lives. All of our grants are to help patients. They aim to reach those in need of the latest development as soon as possible. The dedication of British researchers is encouraging and inspiring. HeartResearchUK is proud to be a part of it. “

Heart Research UK, CEO, Kate Bratt-Farrar

Heart Research UK is funding a new project to investigate the effects of COVID-19 on blood vessels and blood pressure

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