Researchers at HSE University have discovered the world’s first genetic predisposition to severe COVID-19.The results of the study were published in the journal Immunology Frontier..
T cells Immunity is one of the important mechanisms used by the human body to combat viral infections. The stage for the development of cell-mediated immunity is the presence of viral peptides on the surface of infected cells. This is followed by activation of T lymphocytes, which begin to kill infected cells. The ability to successfully present viral peptides is primarily determined by genetics.
In human cells, human leukocytes antigen Class I (HLA-I) molecules are responsible for this presentation. Such a set of six molecules is unique to all humans and is inherited from the parents of the individual. Simply put, if a set of alleles successfully detects the virus, immune cells quickly detect and destroy the infected cells. If a person has a set that is not good at such detection, it is more likely that cases of more severe illness will be observed.
Researchers in the Faculty of Biology and Biotechnology (Maxim Shkurnikov, Stepan Nersisyan, Alexei Galatenko, Alexander Tonevitsky), along with colleagues from the Piragov Russian National Research and Medical University and Filatov City Clinical Hospital (Tatjana Jankevic, Ivan Gordeev, Valley Vechorko) The interconnect was studied between the HLA-I genotype and the severity of COVID-19.
Using machine learning, we built a model that provides an integrated assessment of the possible forces of the T cell immune response to COVID-19. Those individuals received a low risk score when the set of HLA-I alleles allowed effective presentation of SARS-CoV-2 viral peptides, whereas those with low presentation ability received a high risk score. (Range from 0 to 100). To validate the model, the genotypes of more than 100 patients and more than 400 healthy people (control group) suffering from COVID-19 were analyzed. The modeled risk score proved to be very effective in predicting the severity of COVID-19.
In addition to analyzing Moscow’s population, researchers used their model in a sample of patients from Madrid, Spain. This independent sample also confirmed the high accuracy of the prediction. Patients suffering from severe COVID-19 had a significantly higher risk score than patients with moderate to mild illness.
In addition to the correlations found between genotype and COVID-19 severity, the proposed approach assesses how specific COVID-19 mutations affect the development of T cell immunity to the virus. It also helps to do. For example, infection with a new strain of SARS-CoV-2 will allow us to detect a group of patients that may lead to more serious illness. “
Alexander Nebitsky, Faculty of Biology and Biotechnology, HSE
HSE researchers have discovered a genetic predisposition to the severity of COVID-19
Source link HSE researchers have discovered a genetic predisposition to the severity of COVID-19