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Many children with severe MIS-C exhibit neurological symptoms

By Robert Preidt and Ernie Mundell

Health Day Reporter

Wednesday, April 14, 2021 (HealthDay News)-In rare cases, children were infected New coronavirus It can develop a serious illness known as Pediatric Multisystem Inflammatory Syndrome (MIS-C). Currently, studies show that these young patients often develop neurological symptoms along with respiratory problems that they may face.

These neurological symptoms were found in half of the children hospitalized for MIS-C, UK researchers say.

“With this new inflammatory syndrome that develops after a child is infected with the coronavirus, we are still learning how the syndrome affects children and what we need to be aware of.” Dr. Omar Abdelmannan, a research author at University College London, said. His team will present new discoveries at the American Academy of Neurology’s Virtual Annual Meeting this month.

“We found that many children are experiencing neurological symptoms that involve both the central and peripheral nervous systems,” the researchers explained in an academy news release.

MIS-C is a rare disease that usually occurs in children previously infected with COVID-19. It usually begins about a month after someone becomes infected with COVID-19.

The state is marked by the influx of inflammation It affects the functioning of organs and systems throughout the body. The exact cause is unknown, but MIS-C appears to be rooted in the body’s immune system, which overreacts to the COVID-19 virus. Many children with MIS-C need to be hospitalized, but treatment options are usually successful and most children recover. However, scientists and doctors are still considering potential long-term consequences.

In a new study, Abdel-Mannan’s group found 46 COVID-19 patients under the age of 18 (mean age 10 years) with MIS-C who were admitted to the Great Ormond Street Hospital in London between April and September last year. I analyzed the medical records of.

Of those children, 24 showed new neurological symptoms or signs when they were admitted to the hospital. 24 had headaches, 14 had headaches Encephalopathy (Inflammation of the brain that may be caused by infection), 6 voice abnormalities or hoarseness, 6 illusions, 5 coordination disorder (ataxia), 3 peripheral nerve problems, 1 seizure Woke up.

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Children with neurological symptoms are more likely to have MIS-C, so there are ventilators and medications that help stabilize blood circulation compared to children without such symptoms. I needed it.

“Children who develop this condition should be reliably evaluated for neurological symptoms and long-term cognitive outcomes,” Abdel Mannan believes. He said, “More studies are needed, including more and more children, to see how this condition changes over time and whether there is a longer-term neurocognitive effect. Is needed. “

One US expert said the new discoveries still provide valuable insights into the mysterious illness.

Dr. Michael Grosso, Chief Medical Officer and Dean of Pediatrics at Huntington Hospital in Northwell Health, New York, said:

“Multisystem inflammatory syndrome seems to overlap with the well-known childhood condition known as Kawasaki disease, but it differs in many ways, and it seems that the symptoms vary with the age of the child,” he said. Stated. “The author’s finding that central nervous system involvement is common in MIS-C will be of great help in warning clinicians to look for these problems.”

However, Grosso added that the study is still in its infancy.

“It’s likely that you’ve known about children’s COVID and MIS-C, but that’s just part of what you haven’t learned yet,” he said.

New discoveries were presented at medical conferences and should be considered preliminary until published in a peer-reviewed journal.

For more information

The US Centers for Disease Control and Prevention Pediatric multisystem inflammatory syndrome..

Source: Michael Grosso, MD, Chief Medical Officer and Chair, Pediatrics, Huntington Hospital, Northwell Health, Huntington, NY.American Academy of Neurology, News Release, April 13, 2021

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Many children with severe MIS-C exhibit neurological symptoms

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