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Moderna COVID-19 vaccine trial follows safety protocols, principal investigator says – Kansas City, Missouri

Kansas City, Missouri 2020-11-22 18:49:28 –

Kansas City, Missouri — The COVID-19 vaccine, which is gaining momentum in medical trials, could be 95% effective, according to the lead investigators in the Moderna trial.

Dr. Spyros Kalams, an associate professor of infectious diseases at Vanderbilt University Medical Center, was in charge of the Moderna trial in August.

“Is the first goal really to prevent people from getting sick? It definitely looks like that in the short term,” Columns said.

As of Sunday, Moderna’s vaccine is almost 95% effective.

Pfizer also reports that the vaccine is 95% effective.

How is the effective rate determined?

Over 30,000 participants have registered for the Moderna trial. Each person received two shots every four weeks. One shot is a vaccine and the other injection is a placebo.

“I don’t know who gets what,” Karams said. “Participants do not know who will get what. Then wait. Symptoms accumulate.”

Whenever participants experience symptoms within a few days of receiving a shot, they report it in their diary, Karams said.

“We need to determine if it sounds like a reaction to the vaccine or if it’s a real infection,” Karams said. “If they actually sound like they are infected with COVID, they come to a sick visit, wipe their noses, and draw blood.”

All infections are then reported to an independent monitoring committee.

Of the more than 30,000 participants, 95 reported symptoms consistent with COVID-19. According to Karams, the majority of cases received placebo.

Eleven of the 95 people who reported symptoms became seriously ill. All of them belonged to the placebo group, which means they were not vaccinated, Karams said.

Moderna used this data to determine the effectiveness of the vaccine.

“This basically shows that within 3-4 months of the second shot, COVID disease is 95% protected,” says Kalams.

Is the vaccine safe?

Although the testing process has been streamlined, Kalams said no steps were skipped when it came to safety.

“Most of the speed was to get rid of some of the bureaucratic bureaucratic formalism,” Columns said.

According to Kalams, hiring a team of researchers usually takes 12-18 months. But for the COVID-19 vaccine, Mr. Karams said he was able to hire a team immediately because the funding was provided by the National Institutes of Health.

“I understand this was quick, but all safety protocols were followed,” Karams said. “I don’t know anything that could have been better to make sure the vaccine was safe.”

Vaccine-related illness

Most illnesses under study were reported within the placebo group. However, according to Karams, people can feel sick after being vaccinated.

He said arm pain, malaise, and headaches were among the symptoms.

“Don’t think of this as an adverse event,” Karams said. “You have an immune response, and that’s actually a good thing.”

According to Kalams, the vaccine does not contain the virus, so COVID-19 cannot be obtained from the vaccine.

“There are small pieces of RNA (ribonucleic acid) that make up a small portion of the spike protein, and an immune response occurs against it,” Karams said. “That part of the RNA disappears, then your immune response continues.”

No one died during the trial process.

“Something like that probably stopped the trial to understand what was happening,” Karams said. “There was no safe stop.”

Acquisition of herd immunity

Researchers believe that 70% of the population needs to be exposed to the virus to get herd immunity, which, according to Kalams, will stop the pandemic.

Vaccine false alarm

Connie Satzler of the Immunize Kansas Coalition said vaccines are one of the most effective and important “last century public health tools”.

“These are the tools that give us the greatest promise of influencing this pandemic and bringing everyone back to normal life,” says Satsler, who generally provides science-based factual information about vaccines. Mr. says.

Vaccines for children under the age of 2 have been steadily declining since 2016, according to data from the US Centers for Disease Control and Prevention.

Sattsler said she believed it was related to false information about the vaccine. And she said that false information also stems from fear.

“I encourage people to openly look at scientific and credible information from both sides, rather than lonely voices, rather than looking for information to confirm their concerns,” says Sattsler. I did. “Look for that scientific consensus out there.”

Satzler recommended the History of Vaccines, a website created by a group of doctors. It uncovers myths by providing data on several topics such as side effects.

Click here for details

Moderna’s trial lasts for two years.

Karams said efficacy rates could change as researchers continue to evaluate symptoms.

He said that the length of time people maintain immunity is also likely to change over time.

According to Kalams, researchers are still trying to determine whether the vaccine will prevent COVID-19 infections or just serious illnesses.

“The vaccine may not prevent the infection, but it may just prevent the infection from getting really, really sick,” Karams said. “Further analysis will come out.”

So far, Mr. Karams said the vaccine believes it will prevent people from getting infected with the virus. However, he said some participants may have been infected without symptoms.

Moderna’s next step is to begin testing vaccines in children over the age of 12 and pregnant women.

Moderna COVID-19 vaccine trial follows safety protocols, principal investigator says Source link Moderna COVID-19 vaccine trial follows safety protocols, principal investigator says

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