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Moderna’s vaccine is the most effective, but Pfizer and J&J also protect well, CDC-led study says – Pittsburgh, Pennsylvania

Pittsburgh, Pennsylvania 2021-09-18 21:06:00 –

A direct survey of all three US-approved coronavirus vaccines showed that the Modana vaccine was slightly more effective than Pfizer and could keep people away from the hospital. Johnson & Johnson’s Janssen vaccine is third. However, it still provides 71% protection. The Pfizer vaccine provided 88% protection against hospitalization, and the Moderna vaccine was 93% effective. The US Centers for Disease Control and Prevention led a national study of vaccination of more than 3,600 adults hospitalized with COVID-19 between March and August. In 2021, the Moderna vaccine (93%) was higher than the Pfizer-BioNTech vaccine (88%) and the Janssen vaccine (71%), “the team wrote in the CDC’s weekly report on death and illness, MMWR. Although these actual data suggest that there is some variability in vaccine protection levels, all FDA-approved or approved COVID-19 vaccines are substantial for COVID-19 admission. Provides protection. / BioNtech’s vaccine was driven by a decline that began about four months after people were completely vaccinated with the Pfizer vaccine. Differences in vaccine efficacy between Moderna and Pfizer-BioNTec h vaccines have a high mRNA content in the Moderna vaccine, differences in timing of administration (3 weeks for Pfizer-BioNTech, 4 weeks for Moderna) , Or due to differences between the vaccinated groups that were not considered in the analysis. “The vaccine efficacy of the Pfizer-BioNTech vaccine was 91% 14-120 days after the second vaccination, but dropped significantly to 77% over 120 days,” the team wrote. Both Pfizer and Modana vaccines use a genetic substance called messenger RNA to provide immunity, but the doses and formulations used are slightly different. The Janssen vaccine uses a common inactivated cold virus (viral vector) called adenovirus to carry genetic instructions into the body. Hospitalization for COVID-19 “. “Understanding the differences in vaccine efficacy between vaccine products can guide individual choices and policy recommendations regarding vaccine boosters. All FDA-approved or approved COVID-19 vaccines are COVID-19 hospitalizations. It provides substantial protection against. ”CDC has worked with researchers across the country to study 3,689. Patients in 21 hospitals in 18 states for the study. They also examined antibodies in the blood of 100 healthy volunteers after vaccination with one of the three available vaccines. A single dose regimen of the Janssen viral vector vaccine. Although the observed vaccine efficacy of the Janssen vaccine was low, a single dose of the Janssen vaccine reduced the risk of COVID-19-related hospitalization by 71%, “they wrote. “This analysis did not consider the effectiveness of the vaccine against children, immunocompromised adults, or COVID-19 who did not reach hospitalization,” the team wrote. In addition, volunteers were followed for only 29 weeks, or just over 6 months.

Direct confrontation study Of all three US-approved coronavirus vaccines, the modelna vaccine is slightly more effective than Pfizer in actual use, and the Johnson & Johnson Janssen vaccine is third, but with 71% protection. Provide.

The Pfizer vaccine provided 88% protection against hospitalization, and the Modana vaccine was 93% effective. The US Centers for Disease Control and Prevention led a national study of vaccinations for more than 3,600 adults hospitalized with COVID-19 between March and August.

“The efficacy of the vaccine for COVID-19 hospitalization from March 11 to August 15, 2021 in US adults without immunodeficiency is Pfizer-BioNTech vaccine (88%) and Janssen vaccine (88%). The Moderna vaccine (93%) was higher than 71), “the team wrote in the CDC’s weekly report on death and illness, MMWR.

“While these real-world data suggest that there are some variations in vaccine protection levels, all FDA-approved or approved COVID-19 vaccines provide substantial protection against COVID-19 hospitalization. Will provide. “

They found that the biggest difference between the Moderna vaccine and the Pfizer / BioNtech vaccine was caused by a decline that began about four months after people were completely vaccinated with the Pfizer vaccine.

“The difference in vaccine efficacy between the Moderna and Pfizer-BioNTech vaccines is the high mRNA content of the Moderna vaccine, the timing of administration (3 weeks for Pfizer-BioNTech, 4 weeks for Moderna), or the group. It could be due to the difference between them. I received each vaccine that was not considered in the analysis, “the team wrote.

“The vaccine efficacy of the Pfizer-BioNTech vaccine was 91% 14-120 days after receiving the second vaccine, but dropped significantly to 77% over 120 days,” the team wrote. increase.

Both Pfizer and Modana vaccines use a genetic substance called messenger RNA to provide immunity, but the doses and formulations used are slightly different. The Janssen vaccine uses an inactivated common cold virus (viral vector) called adenovirus to carry genetic instructions into the body.

“A single dose of Janssen viral vector vaccine was relatively ineffective against anti-SARS-CoV-2 antibody response and COVID-19 hospitalization,” the team said. “Understanding the differences in vaccine efficacy between vaccine products can guide individual choices and policy recommendations regarding vaccine boosters. All FDA-approved or approved COVID-19 vaccines are COVID-19 hospitalizations. It provides substantial protection against. ”CDC has worked with researchers across the country to study 3,689. Patients in 21 hospitals in 18 states for the study. They also examined antibodies in the blood of 100 healthy volunteers after being vaccinated with one of the three vaccines available.

“These real-world data suggest that a double-dose Moderna and Pfizer-BioNTech mRNA vaccine regimen provides more protection than a single-dose Janssen viral vector vaccine regimen. Despite the low efficacy of the observed vaccine, the single Janssen vaccine still reduced the risk of COVID-19-related hospitalization by 71%. “

This study had its limits. “This analysis did not consider the effectiveness of the vaccine against children, immunocompromised adults, or COVID-19 who did not reach hospitalization,” the team wrote. In addition, volunteers were followed for only 29 weeks, or just over 6 months.

Moderna’s vaccine is the most effective, but Pfizer and J&J also protect well, CDC-led study says Source link Moderna’s vaccine is the most effective, but Pfizer and J&J also protect well, CDC-led study says

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