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NCCS launches clinical trials to consider the use of TCM to combat cancer-related symptoms

The Singapore National Cancer Center (NCCS) is clinically considering the use of Chinese herbal medicine (TCM) to combat cancer-related symptoms and side effects of cancer treatment to improve the quality of life of cancer survivors. The test has started. Advances in cancer diagnosis and treatment have significantly improved cancer survival, but cancer survivors experience a variety of cancer-related and post-treatment side effects, including cancer-related fatigue. I often experience it.

Cancer-related fatigue (CRF) refers to the painful and persistent sensations of physical, emotional, and / or cognitive fatigue that are side effects of cancer or anticancer treatment. CRF is a frequent experience for cancer survivors and can interfere with their daily functioning. Health-related quality of life interventions in breast and other cancer survivors experiencing CRF using herbal medicine or the HERBAL trial use TCM to manage the side effects experienced by cancer survivors The purpose is to evaluate the benefits of doing.

Currently recommended treatments for CRF include non-pharmacological management such as exercise, cognitive behavioral therapy, and patient education.Pharmacological therapies are still under investigation, but only a limited number have been shown Effectiveness So far. This is partly because the underlying biological mechanisms of CRF have not been fully established.

Many patients continue to show persistent symptoms because the recommended management of CRF is limited in both scope and efficacy. Further research in this area is needed, and culturally appropriate interventions need to be tailored to individual patients. We are observing many patients seeking adjuvant therapy such as TCM to manage their symptoms. “

Dr. Tira Tan, Principal Investigator of the HERBAL Trial and Consultant of NCCS Oncology

The scientific data examining the benefits of TCM was sparse and encouraged a team of researchers to design the HERBAL trial.

Conducting the first TCM trial to control the side effects of cancer treatment

The HERBAL trial evaluates the use of a modified TCM formulation in clinical trials known as Xiang Bei Yang Rong Tang (XBYRT) in alleviating CRF. The formula used in the research was developed by collaborator Alexander Chan, a visiting professor at the NCCS Oncology Pharmacy, in consultation with TCM at the Singapore Tonchai Medical Institution (STCMI).

In the TCM literature, XBYRT is believed to be able to boost qi, nourish the blood, improve appetite, and calm the mind, with the goal of reducing the CRF of cancer survivors.

Zheng Huangfang, Chief Medical Officer and TCM Physician at STCMI, said: “Our observations show that cancer patients generally exhibit stagnant mood and can be caused by psychological distress from the cancer diagnosis, their unique personality, sedentary lifestyle or other factors. Based on this, XBYRT should be effective in treating these types of post-treatment cancer patients. “

The HERBAL trial aims to enroll 80 cancer survivors in a research study examining the use of XBYRT. It is intended for individuals who are in remission from cancer and have completed aggressive treatment, including surgery, chemotherapy, and / or radiation therapy, for at least one month. They will be screened onsite at NCCS by a certified TCM doctor for qi and blood deficiencies prior to enrollment in the study. Participants will be randomized into two groups and will receive TCM treatment or placebo for 8 weeks. Participants’ quality of life, malaise, and cognitive function are assessed at a point in time using well-validated evaluation tools. TCM doctors also evaluate participants’ response to treatment to determine if their qi levels have recovered.

HERBAL exam goals and adoption

The results of this study will be a valuable addition to the existing literature, as currently limited research and scientific data support the use of TCM to manage the symptoms of cancer survivors. The results can provide both clinical and biochemical foundations that guide the design of future studies to facilitate a better understanding of the biological mechanisms that may contribute to the effectiveness of TCM. ..

NCCS launches clinical trials to consider the use of TCM to combat cancer-related symptoms

Source link NCCS launches clinical trials to consider the use of TCM to combat cancer-related symptoms

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