Pediatric laryngeal tracheal stenosis (LTS), which is a pediatric airway stenosis, is a complex condition. It can be the result of a child being born or injured, but this condition can cause life-threatening emergencies if left untreated.
However, treatment is difficult. Depending on the severity, doctors combine endoscopic techniques, surgical repair, tracheostomy, or stent deployment to keep the airways open and allow breathing.
Stents are good at keeping the airways open and keeping the trachea growing, but they can move or cause damage when they are finally removed.New research published in Communication biology The University of Pittsburgh is poised to significantly improve the use of stents, demonstrating for the first time the successful use of fully biodegradable magnesium alloy tracheal stents that avoid some of these risks. ..
The use of over-the-counter non-biodegradable metal or silicone-based tracheal stents carries the risk of serious complications and does not achieve optimal clinical outcomes even in adults. The use of advanced biomaterials has the potential to provide less invasive and more successful treatment options. “
Prashant N. Kumta, Edward R. Weidlein Professor of Biotechnology, Swanson Institute of Technology
In this study, balloon-expandable ultra-high ductility (UHD) biodegradable magnesium stents performed better than current metal non-biodegradable stents used in both lab tests and rabbit models. Shown. Stents have been shown to keep the airways open for extended periods of time, have a low rate of degradation, show normal healing, and have no harmful problems.
“Our results are very promising for the use of this new biodegradable, highly ductile metal stent, especially for pediatric patients,” said the McGowan Institute of Regenerative in Chemistry and Petroleum Engineering, Mechanical Engineering and Materials Science. But appointed Kumtah says. medicine. “We hope that this new approach will lead to new and improved treatments not only for patients with this complex condition, but also for patients with other tracheal obstructions, including tracheal cancer.”
Woo, J. , et al. (2020) In vivo efficacy of biodegradable ultra-high ductile Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction. Communication biology. doi.org/10.1038/s42003-020-01400-7.
New biodegradable magnesium alloy tracheal stent for children with airway obstruction
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