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New discoveries reveal why certain COVID patients die

“Interferon is like a combination of a fire alarm and a sprinkler system,” said Rasmussen, who was not involved in the new research.

In some people with COVID-19, interferon is probably suppressed by the virus itself, according to laboratory studies.

Interferon is especially important for protecting the body from new viruses such as the coronavirus that the body has never encountered, said Chan, a researcher at the St. Giles Infectious Diseases Genetics Institute at Rockefeller University. It was.

“Your body should sound an alarm everywhere,” Zhang said when infected with the new coronavirus. “If the alarm doesn’t sound, there can be a lot of viruses everywhere.”

Importantly, the patient did not make autoantibodies in response to the virus. Instead, they seemed to have them before the pandemic began, said Paul Busterd, the lead author of antibody research and a researcher at Rockefeller University.

Autoantibodies did not cause problems until the patient was infected with COVID-19 for reasons the researchers did not understand, Bastard said. For some reason, the new coronavirus, or the immune response it caused, seems to have driven them.

“Before COVID, their condition was silent,” Bastard said. “Most of them have never been ill before.”

Bastard said he suspects that autoantibodies to interferon may also increase the risk of other viruses such as influenza. Some of the patients who participated in his study said, “Some patients have had the flu in the past. We are investigating whether autoantibodies may be affecting the flu.”

Sabrakline, a professor of molecular microbiology and immunology at the Johns Hopkins Bloomberg School, has evolved the way viruses and the immune system compete in a sort of armed competition, evading the immune system and suppressing its response. Scientists have long known that they are. Of public health.

Antibodies are usually heroes of the immune system and protect the body from viruses and other threats. However, a phenomenon known as an autoimmune disease can cause the immune system to appear disrupted and produce autoantibodies. It occurs in diseases such as rheumatoid arthritis, in which antibodies attack the joints, and type 1 diabetes, in which the immune system attacks insulin-producing cells in the pancreas.

New discoveries reveal why certain COVID patients die

Source link New discoveries reveal why certain COVID patients die

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