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New insights into how inpatients develop liver damage by taking different medications

New research published in British Journal of Clinical Pharmacology It provides insight into how the average inpatient can develop liver damage by taking a variety of medications.

When researchers analyzed the records of 156,570 inpatients, they found 499 drug-induced liver injury (DILI) with an incidence of 0.32%. Anti-infectives, cancer treatments, and non-steroidal anti-inflammatory drugs are the major categories of drugs that cause DILI, with the highest incidence due to voriconazole (antifungal drug). Patients with high cholesterol, cardiovascular disease, existing liver disease, and previous surgery were at increased risk of DILI.

DILI-related real-world studies were conducted with the help of information technology to provide more accurate references for safe and rational substance use. “

Dai Hong Guo, Corresponding Author of PLA General Hospital in Beijing

Source:

Journal reference:

Kong, X. , et al. (2021) Incidence, characteristics and risk factors for drug-induced liver injury in inpatients: a consistent case-control study. British journal of clinical pharmacology. doi.org/10.1111/bcp.14847..

New insights into how inpatients develop liver damage by taking different medications

Source link New insights into how inpatients develop liver damage by taking different medications

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