According to a new study in Japan, people over the age of 100 may have special gut bacteria that help prevent infection.
This result suggests that these bacteria and the specific compounds they produce (known as “secondary bile acids”) may contribute to a healthy intestine and thus healthy aging. increase.
Still, more research is needed to find out if these bacteria promote very long lifespans.Current findings published in the journal on Thursday (July 29) Nature, Only the association between these gut bacteria and living over 100 years is shown. The lead author of the study, Dr. Honda Kenya, a professor of microbiological immunity at Keio University School of Medicine, said he did not prove that these bacteria caused people to live longer.
“It may suggest that these bile acid-producing bacteria may contribute to prolonging lifespan, but there are no data showing a causal relationship between them,” Honda told Live Science. rice field.
Related: How long can humans live?
“Signature” of gut microbiota
The community of bacteria and other microorganisms that live in the gut, known as the gut flora, plays a role in our health and is known to change with age. For example, the low diversity of gut microbiota is associated with frailty in the elderly. However, researchers suspected that people over the age of 100 might have special gut bacteria that contribute to their health. That’s right People over 100 years old Compared to older people who do not reach this milestone, they tend to have a lower risk of chronic illness and infection.
In a new study, researchers examined the gut microbiota of 160 people over the age of 100, who averaged 107 years. They compared the gut microbiota over 100 years with 112 people aged 85-89 and 47 people aged 21-55.
They found that people over the age of 100 had distinct “characteristics” of gut microbiota not found in the other two age groups. For example, certain types of bacteria were concentrated or depleted in people over 100 years of age compared to the other two groups.
Researchers then analyzed intestinal metabolites in all three groups and found that people over the age of 100 had significantly higher levels of so-called secondary bile acids compared to the other two groups. I found that.
Bile is a yellow-green liquid made by liver Will be saved in gall bladder, by National Institute of Health.. Bile acids are compounds in bile that help digest fat in particular. According to a 2009 paper published in the journal, after the liver produces bile acids, they are released into the intestine, where bacteria chemically modify them to secondary bile acids. Diabetes care..
Researchers have found that people over the age of 100 have particularly high levels of secondary bile acids called isoalloLCA. The authors set out to identify the pathway because they did not know which metabolic process the bacteria used to produce isoallo LCA. They screened a 110-year-old gut bacterial strain that had particularly high levels of secondary bile acids and found that a family member called Odoribacteraceae produces isoallo LCA.
In addition, isoallo LCA was found to have strong antibacterial properties. That is, it can inhibit the growth of “bad” bacteria in the intestines.In laboratory dish and mouse experiments, the authors found that isoallo LCA slows growth. Clostridium difficileBacteria that cause severe diarrhea and inflammation of the colon. IsoalloLCA also suppressed the growth of vancomycin-resistant enterococci, a type of antibiotic-resistant strain known to cause infections in hospitals.
Findings suggest that isoallo LCA may contribute to a healthy gut by preventing the growth of bad bacteria.
They also suggest that these bacteria or their bile acids can be treated or prevented. C. Difficile Honda said more research was needed to show this, but said it was an infectious disease in people.
Honda said that if these bile acid-producing bacteria contribute to gut health, they could one day be used as probiotics to improve human health. He said these bacteria look safe because they do not produce toxins and do not carry antibiotic resistance genes.
It is unclear how people over the age of 100 will acquire these beneficial bacteria, but both genetics and diet may play a role in shaping the composition of people’s gut flora. Honda said there is.
This study did not collect information about participants’ diet, exercise habits, or drug use. All of these affect the gut flora and can help explain the association.
Future studies that track large numbers of people over the long term may further investigate the association between these bacteria and longevity.
Originally published in Live Science.
People living up to 100 years have unique gut microbiota characteristics
Source link People living up to 100 years have unique gut microbiota characteristics