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Professor UTHSC receives $ 2.87 million to study genetic changes associated with Gulf War disease

The National Institute of Environmental Health Sciences has named Dr. Byron C. Jones, a professor of genetics, genomics, and informatics at the University of Tennessee Health Sciences Center for continued research on genetic changes associated with Gulf War disease. Awarded $ 2.87 million. Among former military personnel.

During the 1990-91 Gulf War, 700,000 troops were sent to the Persian Gulf. Of those returning home, 25% -35% suffered from what became known as the Gulf War illness. It is a dissatisfied, multi-symptomatic illness that ranges from gastrointestinal problems to cognitive impairment. The behavior of the illness was incapacitated, and no cause or cure was known. Almost 30 years later, most of the suffering people are still ill. Exposure to organophosphorus compounds (nerve agents and pesticides), coupled with a high stress environment, has emerged as a possible cause of the disease and a focus of research.

Dr. Jones’ project, based on past research conducted by his lab, identifies why some combatants became ill and some did not. Dr. Jones’ team previously identified genes and biochemical pathways involved in individual susceptibility by replicating exposure conditions in animal models.

Focusing on these systems, his team looks for gene-based individual differences in which gene expression changes permanently after the same exposure. The findings from this project provide a better understanding of which biochemical processes are involved and provide the basis for developing treatments.

Early studies have shown abrupt changes in pro-inflammatory cytokine genes and changes in gene methylation after exposure regimens. Significant differences in the pro-inflammatory gene expression response to treatment were seen between animal models and could be mapped to regions of DNA that mediate this effect. Our study takes the next step in understanding how genetics is associated with the ongoing effects of Gulf War disease. “

Dr. Byron C. Jones, Professor, Center for Health Sciences, University of Tennessee

The study entitled “Genetics of Epigenetic Responses to Highly Inflammatory Reducing Hormones and Environmental Compounds” has been funded for five years.

Professor UTHSC receives $ 2.87 million to study genetic changes associated with Gulf War disease

Source link Professor UTHSC receives $ 2.87 million to study genetic changes associated with Gulf War disease

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