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Researchers are developing nanopharmaceutical mask fabrics to prevent SARS-CoV-2 infection

As Coronavirus Disease 2019 (COVID-19) continues to spread worldwide, countries are adapting to new normals. This includes wearing face masks, protective clothing, face shields, and practicing social distance.

These non-pharmacological interventions (NPIs) help reduce infection with the virus that causes COVID-19, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).

Face masks have become a regular tool for people, even if they are not healthcare professionals. Initially, masks were intended to protect the people around them. Currently, wearers also use face masks to protect themselves from others.

To ensure protection of the wearer from viral droplets from infected individuals, it is necessary to find a fabric that is effective, antibacterial and comfortable for face masks and personal protective clothing (PPE). ..

Properly sensitized with non-toxic zinc oxide nanoflowers, the new nanopharmaceutical cotton cloth can be used as a membrane filter for one-way valves in face masks to control the source of COVID-19 infection and ensure respiratory comfort. There is a possibility.Nanocutical fabric denatures SARS-CoV-2 Spike protein Disables microorganisms.

Researchers at the SN Bose National Center for Fundamental Sciences in West Bengal have found that comfortable, washable, antibacterial nanopharmaceutical fabrics can prevent viral infections.

Face mask problem

Personal Protective Equipment (PPE) covers a variety of materials and tools used to reduce the transmission of respiratory droplets from infected individuals. Not only can you protect others, but you can also protect your wearer from being infected by a virus.

The US Centers for Disease Control and Prevention (CDC) has warned against using unidirectional vents or valves on face masks as they can promote viral infections. It can also cause serious discomfort and health problems.

Previous studies have suggested that commonly available N95 face masks can cause changes in blood oxygen and carbon dioxide levels with long-term use. These changes are common in the elderly, obese, or people with chronic obstructive pulmonary disease (COPD).

Other health effects include increased heart rate, increased blood pressure, hypercapnia or increased carbon dioxide levels, and chest pain. One solution is to cover the vent with a porous filter that can trap or kill microorganisms such as viruses.

To date, there is no research to develop such a filter. Developing filters made of natural fibers with embedded antibacterial agents can be an effective solution.

the study

Studies published in preprint journals bioRxiv* server, We considered using a new nanopharmaceutical cotton cloth properly sensitized with non-toxic zinc oxide (ZnO) nanoflowers, which can be used as a membrane filter for one-way valves in face masks to ensure breathing comfort. Apart from this, it can also protect the wearer from COVID-19 infection.

Nanocutical fabrics can alter the SARS-CoV-2 peplomer and nullify the virus.

To reach the findings, a team of researchers conducted a comprehensive computer-assisted simulation study to uncover the unique potential of ZnO nanoflowers. They have a two-dimensional nanopetal for the capture and denaturation of SARS-CoV-2 peplomer and kill the virus.

In addition, the team synthesized ZnONF on a natural cotton fiber matrix using a one-pot hydrothermal support approach.They also tested the antibacterial properties of the fabric through a thorough antibacterial study using capsules containing: Pseudomonas aerugnosa, It shares similar homology with coronavirus peplomer.

Research results have shown that the developed nanocutical fabric filter has excellent antibacterial efficiency.

In our understanding, the new nanopharmaceutical fabric used in the one-way valve of face masks will be the choice to control the source of COVID-19 infection and ensure respiratory comfort, “the team said. It is stated in. “The developed nano-sensitized fabric can generally be further used as an antibacterial (and anti-SARS CoV-2) dress material to prevent nosocomial infections,” they added.

The research team has succeeded in using a commonly available cotton fabric infused with ZnO nanoflowers. The resulting product was effective in destroying microbial membranes and inhibiting infection.

To further test the product, they designed a laboratory-grade prototype respirator using a regular N95 mask with ZnO nanoflower cotton fabric. The porous and lightweight respirator solves the common problem of carbon dioxide rebreathing and prevents the spread of microorganisms through the pores.

This new product could be used to manufacture masks and PPEs that are in urgent need today, especially for healthcare professionals at the forefront of pandemics.

To date, more than 111.75 million COVID-19s have occurred worldwide. Of these, 2.47 million died.

*Important Notices

bioRxiv Publish preliminary scientific reports that should not be considered definitive as they are not peer-reviewed, guide clinical practice / health-related behaviors, and should not be treated as established information.

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Researchers are developing nanopharmaceutical mask fabrics to prevent SARS-CoV-2 infection

Source link Researchers are developing nanopharmaceutical mask fabrics to prevent SARS-CoV-2 infection

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