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Researchers develop the first plant-based gels to support the growth of organoids for biomedical applications

Researchers at Monash University have created the world’s first bioactive plant-based nanocellulose hydrogel that supports the growth of organoids and helps significantly reduce the cost of cancer and COVID-19 research.

This discovery by researchers at BioPRIA (Australia’s Institute for Bioresource Processing), Monash University’s Faculty of Chemical Engineering, and Monash Institute for Biomedical Discovery will develop organicoids cheaper, faster, and more ethically.

Hydrogels can also improve drug screening and disease modeling for infectious diseases such as COVID-19. Metabolic diseases such as obesity and diabetes; and cancer.

Survey results published in Advanced science, Emerge as a promising discovery for the growth of organoids for essential laboratory tests around the world. With additional testing, this hydrogel may be available to researchers and healthcare professionals around the world within 12 months.

Nanocellulose gels cost just a few cents per 10 ml used, compared to the current gold standard of over $ 600.

Above all, nanocellulose gels are completely plant-based and prevent the harvesting of animal organs and unknown biomolecules for advanced medical testing.

The research was led by Professor Gil Garnier and Dr. Rodrigo Curvello of BioPRIA, Department of Chemical Engineering, Monash University.

Organoids provide robust models for key biomedical applications such as drug screening and disease modeling.However, current approaches are still expensive, biochemically variable and undefined... “

Gil Garnier, Director of BioPRIA, Monash University

“These are major obstacles to basic research and translation of organoids into clinics. To significantly reduce costs and eliminate the reliability of unknown biomolecules, we need an alternative matrix that can sustain the organoid system. ..

“Since nanocellulose hydrogels are animal-free, their composition is completely controlled, reproducible and perfectly mimicking the condition of the human body, unlike current advances.”

Organoids are three-dimensional, miniaturized, and simplified versions of in vitro-generated organs that can reproduce the behavior and function of developed organs.

Organoids, commonly referred to as “organs in the dish” or “mini-organs,” are excellent tools for studying basic biological processes. Through organoids, we can understand how cells interact in organs, how disease affects them, and the effects of drugs on disease relief.

Organoids are produced from embryonic, adult, pluripotent or induced pluripotent stem cells, as well as primary healthy or cancerous tissue.

For long-term use, organoids are usually implanted within the Engelbreth-Holm Swarm (EHS) matrix derived from the reconstituted basement membrane of mouse sarcomas.

Currently, organoid cultures rely on this expensive, undefined tumor-derived material, hampering its application to high-throughput screening, regenerative medicine, and diagnostics.

“Our study was basically able to use engineered plant-based nanocellulose hydrogels that could reproduce the growth of small intestinal organoids from mice,” said Dr. Curvello.

“It is essentially made from 99.9% water and only 0.1% solid and is functionalized with a single cell adhesion peptide. Cellulose nanofibers provide the microenvironment needed for the growth and proliferation of small intestinal organoids. Combined with salt.

“Artificial nanocellulose gels are a sustainable alternative to the growth of organoids, helping to reduce the cost of research on diseases of global concern, especially in developing countries.”


Journal reference:

Curvello, R. , et al. (2020) Plant-based nanocellulose hydrogel designed for small intestinal organoid growth. Advanced science.

Researchers develop the first plant-based gels to support the growth of organoids for biomedical applications

Source link Researchers develop the first plant-based gels to support the growth of organoids for biomedical applications

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