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Researchers study protection against COVID over time – Colorado Springs, Colorado

Colorado Springs, Colorado 2022-05-04 13:51:15 –

Chicago — According to data from the US Center for Disease Control and Prevention, nearly 60% of the US population has COVID-19 antibodies from infection, and more than 100 million people are fully vaccinated and boosted. Researchers are trying to find out how much the COVID-19 antibody, whether by infection or vaccination, declines over time.

Alan Randy, a scientist studying immunity and new pathogens, is himself one of the subjects of a large two-year study measuring COVID-19 vaccine antibody levels over time.

“I’m not infected with COVID, so it’s very intriguing to see how my immune system responded,” Randy said.

Due to mask obligations and the loss of social distance, many may wonder how weakened their immunity is and whether boosters are needed.

“What does that mean to me as an individual living and traveling in society and among all my friends, family and relatives?” Randy asked.

Dr. James Moy, an associate professor of immunology at Rush University Medical Center in Chicago, is trying to answer these questions. Since the first vaccine was launched, he has followed 1,100 healthcare workers like Landay after vaccination.

“We started drawing blood for several weeks after the second dose of the vaccine, and then every three months to see how long the antibody lasts,” Moy said. I am saying.

According to Moi, the antibody will eventually drop significantly after the second shot.

“In our study, which examined antibody levels in people after 5 months, they were already 80% lower than peak levels,” he said.

“Coronaviruses and vaccines that help prevent them have strange things that limit the length of immunity that lasts,” says Robert, executive director of the Haby Global Health Institute at the Fineberg School of Medicine, Northwestern University. Dr. Murphy said.

The recently released data from the CDC further reveals how much it is.

Two doses of the Johnson & Johnson vaccine are 30% effective between 2 and 4 months after injection. A single dose of Johnson & Johnson and a single mRNA shot from Pfizer or Moderna are 55% effective. And three doses of mRNA shots are 63% effective between 2 and 4 months.

“If you decide,’I’m not taking these boosters anymore, I have enough.’ What do you guess? In two years, your immunity is basic. There will be nothing in it, “Murphy said.

According to Moy’s study, antibody levels after booster rise again and appear to fall much slower.

“About six months later, I examined my blood. Before I got the booster, my blood had dropped almost 10 times, then I was boosted and it got another 10 times,” Landay said. rice field.

However, antibodies do not convey the big picture.

“T cells are very important to viruses and probably more important than antibodies. Unfortunately, there are no rapid lab tests to assess T cell function,” says Moy.

Another looming question is how mutations affect protection over time. Data already show that COVID reinfections occur more frequently, and in some cases more than once within 90 days.

“It depends on how quickly the virus mutates to the next variant,” Moy said. “So it mutates faster, and your immune response isn’t that good against the mutant, and yes, you’ll get another infection.”

“It’s just changing around all protection,” Murphy said.

For future protection, both Moderna and Pfizer are developing new versions of the vaccine aimed at replacing boosters.

“With COVID, influenza vaccinations are different and the same thing happens. We will probably be vaccinated with various coronavirus vaccines on a regular basis, perhaps even once a year,” Murphy said.

The hope is to provide stronger and longer lasting protection against the original virus and emerging new variants.



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