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Researchers use a new approach to create replacement biological parts

The final creation of a replacement biological component requires full 3D functionality not provided by 2D and 3D thin film bioprinting.

Now, engineers at Penn State University can use yield stress gels to accurately place small aggregates of cells where they want to build the complex shapes needed to replace bone, cartilage, and other tissues. ..

This is important because current cell aggregate bioprinting techniques cannot create complex configurations, most of which are 2D and 3D thin films or simple configurations. “” If you need complex 3D, you need a support field... “

Ibrahim T. Ozbolat, Associate Professor of Engineering Science and Mechanics, Pennsylvania State University, Hearts Family Career Development

The field of support, researchers will report today (October 16) Communication physics Yield stress gel. Yield stress gels are unusual in that they turn into solid gels without stress, but they turn into liquids when stressed.

Suction support bioprinting system The stress of the suction nozzle on the gel liquefies it, but when the suction nozzle releases cell aggregates and withdraws, the gel returns to a solid and self-heals. Small balls of cells overlap each other and self-assemble, creating a solid tissue sample in the gel.

Researchers can place different types of cells together in small aggregates to form the required shape with the required function. Geometric shapes such as cartilage rings that support the trachea can be hung in the gel.

“I tried two gels, but the first one was a little difficult to remove,” said Osborat. “We had to do that by washing. For the second gel, we used an enzyme that liquefies the gel and easily removes it.”

“It’s very important what we’re doing because we’re trying to recreate nature,” said Dishary Banerjee, a postdoctoral fellow in engineering science and mechanics. “With this technology, it is very important to be able to create complex free-form shapes from spheroids.”

Researchers have used different approaches to create theoretical models for a physical understanding of what is happening. We then used experiments to test whether this method could generate complex shapes.

Source:

Journal reference:

Ayan, B. , et al.. (2020) Suction support freeform bioprinting of prefabricated tissue spheroids in yield stress gel. Communication physics. doi.org/10.1038/s42005-020-00449-4.

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