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Severity of COVID-19 illness may depend on levels of one protein – Nashville-Davidson, Tennessee

Nashville-Davidson, Tennessee 2021-09-25 12:11:39 –

Coronavirus delta mutant. (File / Getty)

(StudyFinds) – One protein that scientists say to the human immune system to signal “don’t eat me” could be responsible for people with more severe cases of COVID-19 there is. Researchers at the University of Kent have discovered that high levels of this protein on the surface of infected cells can prevent the immune system from doing its job.

Many patients infected with SARS-CoV-2, the virus that causes COVID-19, develop only mild symptoms, while others experience severe and life-threatening reactions. COVID-19 is already responsible Almost 700,000 people died In the United States. New discoveries reveal that the protein CD47 may play a major role in these deaths.

“Don’t eat me” signal tricks the immune system

The CD47 sends a signal that prevents the immune system’s defenses from accidentally destroying healthy cells. However, researchers have found that when SARS-CoV-2 infects human cells, more CD47s appear on the cell surface. The team adds that this is likely to prevent the immune system from recognizing infected cells as a threat. If the immune system does not attack these cells, the virus can continue to replicate and cause more serious symptoms.

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The authors of the study add specific risk factors for severe COVID-19 infection — Like old age Existing conditions such as diabetes — also show links to higher CD47s Protein level..High CD47 levels also contribute to high blood pressure — another risk factor Severe COVID complications.

Researchers note that treatments targeting CD47 are already under development. Their findings are COVID 19 pandemic.

“This is exciting. We may have identified a major factor associated with severe COVID-19. This is a major step in combating this disease and we look forward to further advances in treatment design. “We do,” said Professor Martin Michaelis. Media release.

“These additional insights into the underlying disease process of COVID-19 not only help us design better treatments, but also help us understand the importance of the breadth of research being conducted. Maybe. Through this path, we have made great strides and demonstrated that the fight against disease continues, “adds Professor Jindrich Sinattle of Goethe University Frankfurt.

The study will be displayed in the journal Current problems in molecular biology..

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