Las Vegas, Nevada 2021-05-08 17:18:08 –
San Diego (KGTV)-From renal failure to heart damage to stroke, COVID-19 can cause a wide range of complications from head to toe. A new study by a team of scientists at the Salk Institute for Biological Studies in La Jolla helps explain why.
Research published in Circular research Make sure that the virus attacks the cells that line the blood vessels. As blood vessels nourish all organs, these vascular endothelial cells provide a foothold for the virus and attack the entire body.
However, researchers’ main findings are that the infamous spikes that coat SARS-CoV-2 play a greater role in the disease than previously thought.
“Peplomer alone can damage,” said Urimanner, an assistant professor of research and co-author of the study.
Scientists have known for some time that the characteristic spike protein of the coronavirus allows cells to unlock and invade cells, but Salk researchers have found that the protein itself. We recorded how cells are damaged when they bind to superficial receptors.
“It causes this massive change in cell signaling and ultimately damages mitochondria,” Manor said.
Mitochondria are the power source in cells. Damage to them can have long-term consequences, Manor said.
He said that mitochondria are “the cell’s major signaling hubs that are involved in inflammation and tell the cells when they die and when they live as they age.”
Researchers have uncovered the effects of peaplomers by building a fake virus known as a pseudovirus. The particles were coated with peplomer, but could not replicate like a virus.
The team then exposed the hamster to the pseudovirus and conducted other experiments in cell culture. According to Manor, the pseudoviral approach allowed researchers to isolate the effects of peplomers.
“What we were trying to do was to simulate what was happening in our body during a large-scale COVID infection,” Manor said. “What we saw was that peplomer proteins that bind to the ACE-2 receptor cause mitochondrial damage.”
According to the laboratory, this was the first study to show that only peplomer can damage mitochondria and could spark new research on more effective treatments.