Scientists have recently found that exercise fills muscles with microscopic tears, so after rigorous exercise, the control center of muscle cells, called the nucleus, scoops towards these small injuries and repairs them. Help.
The new study was published in the journal on October 14th. Chemistry, Researchers have discovered a previously unknown repair mechanism that works after running on a treadmill. Impressive images show how the nucleus is torn towards a crevice in muscle fibers shortly after the end of exercise, commanding the construction of new proteins to seal the wound.That same process will probably develop on your own cell A few hours after I got home from the gym.
The authors of the study found that “the nucleus moved toward the site of injury within 5 hours of injury.” Chemistry.. And within just 24 hours of the injury, the repair process was “almost complete.”
Skeleton muscleAllows spontaneous movements such as walking and is composed of many thin tubular cells. These cells are also called “muscle fibers” because of their thread-like appearance. A single muscle can contain hundreds to thousands of muscle fibers. According to the National Cancer Institute.. Each fiber also contains a unit of contraction machinery called sarcomere that contracts and stretches during exercise.
Eccentric contractions, which force muscles to stretch during contraction, can cause these sarcomere to stretch excessively. (In the second half of the biceps curl, the dumbbell is slowly lowered from shoulder height to the side and downhill is an example of this type of exercise.) If the sarcomere stretches excessively during eccentricity, You can pull the surrounding membrane. According to a 2001 review published in, causing damage Journal of Physiology..
In these situations, muscle cells rely on a skilled cell pit crew to help correct them. Previous the study Have got It has been shown that a few seconds after exercise damage occurs, various proteins form “caps” in and near the damaged area of the membrane. MitochondriaThe so-called cellular powerhouse helps absorb excess calcium that has entered the cells through tears, as muscle cells need to be checked for the amount of calcium in order to function properly.
And now, new research suggests that muscle cell nuclei also rush to help.
In this study, researchers placed adult mice on a treadmill tilted downwards and sampled muscle fibers from animals after a jogging session. In addition, we asked 15 healthy human volunteers to run on a (human-sized) treadmill and biopsy muscle fibers from the vastus lateralis muscle, which is part of the quadriceps.
Related: Does running build muscle?
They found that in both mouse and human muscle fibers, proteins accumulate around the tears of the fibers and form “scars” within 5 hours of exercise. Also, in the muscle fibers sampled 24 hours after exercise, the clusters of nuclei approached tears, whereas in the 5-hour sample, the nuclei appeared far away. To see exactly how the nuclei moved towards the site of injury, the team grew mouse muscle cells in a laboratory dish and zapping them with a laser to mimic exercise damage.
In laboratory-grown cells, nuclei gathered around the laser injury within 5 hours, creating “hot spots” of protein construction in the immediate vicinity. Specifically, following the movement of the nucleus, mRNA A kind of gene instruction manual incorporated into molecules and nuclei. mRNA essentially copies a blueprint encoded in DNA They can then be carried into cells where new proteins can be built. The newly constructed protein helps seal and reconstruct damaged muscle cells.
In the future, medical therapies targeting molecular pathways that allow the nucleus to migrate and initiate this repair process may be devised. It may help accelerate patient recovery after muscle injury, McNally and Demon Brune wrote in their commentary.
Interestingly, the authors also found that mice trained on a treadmill prior to the study developed less scarring on muscle fibers than mice that had not undergone prior training. This is consistent with previous evidence that consistent training strengthens muscles and reduces the tendency to tear during trained movements. According to the New York Times..
Originally published in Live Science.
Stunning images show how muscles heal after training
Source link Stunning images show how muscles heal after training