Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a novel coronavirus, was first detected in Wuhan, China in December 2019, causing a pandemic of coronavirus disease 2019 (COVID-19). It was.
COVID-19 is a highly infectious disease that has spread to more than 191 countries and territories worldwide. To date, 97.61 million cases have been confirmed and more than 2 million have died.
Whole genome sequencing and phylogenetic analysis show that SARS-CoV-2 is associated with SARS bat virus. However, the main and intermediate pathways for SARS-CoV-2’s jump to humans remain unknown. Researchers continue to investigate what, when, and how this zoonotic disease occurred. Meanwhile, clinical trials are underway to find effective antivirals and preventative vaccines for COVID-19.
A team of Chinese researchers from Guangzhou University of Chinese Medicine and Yunnan University of Traditional Chinese Medicine recently investigated the therapeutic properties of Yin Bridge powder in the treatment of COVID-19 symptoms.Their findings are recent Phytotherapy research.
Can Traditional Herbal Medicines Help Treat COVID-19 Symptoms?
Chinese Medicine (TCM) has a comprehensive system that plays an important role in the prevention and treatment of infectious diseases. Several states in China have followed TCM-based prevention and treatment plans for COVID-19 with remarkable results.
After more than 2,000 years of development, Chinese Medicine (TCM) has formed a comprehensive and unique system from disease diagnosis to prognosis. It plays an important role in the prevention and treatment of human infectious diseases. “
Based on big data analysis, Yinqiao powder was found to be the basic formulation used to treat the early stages of COVID-19. According to pharmacological studies, Yinqiao powder has antitussive and expectorant effects, reduces acute lung damage, improves lung function, relieves pulmonary fibrosis, improves the immune response to viruses, and is a modern drug. Relieves side effects.
Active ingredients of Yinqiao powder and its main functions
The active ingredient of Yinqiao powder was identified using high performance liquid chromatography analysis. Rutin and hesperidin. Rutin binds to the major protease of SARS-CoV-2 (3CLpro) with a higher affinity than drugs such as remdesivir, chloroquine and hydroxychloroquine. Studies have shown that rutin may inhibit SARS-CoV-2 by down-regulating interleukin-6 (IL-6).
Hesperidin, on the other hand, has been shown to have inhibitory effects on human angiotensin converting enzyme 2 (ACE2), GRP78, TMPRSS2, and AT1R receptors, and may be effective in treating COVID-19. Although some bioactive substances have been investigated for their ability to treat COVID-19, detailed studies of the ability of Yinqiao powder to treat COVID-19 are sparse.
Investigation of active ingredients and potential mechanisms of Yinqiao powder in COVID-19 treatment
Researchers have recently used several techniques to analyze the active ingredients, targets, and possible mechanisms of Yinqiao powder in the treatment of COVID-19. They include techniques such as target selection and DisGeNET scoring, protein-protein interaction network construction, drug-component-gene network construction, molecular docking, surface plasmon resonance (SPR) analysis, gene tissue analysis, and gene ontology (GO) function analysis. Was used. Kyoto Encyclopedia (KEGG) pathway analysis of genes and genomes.
Researchers also predicted the therapeutic effect of Yinqiao powder with the help of TCManti-COVID-19 (TCMATCOV). The intervention score for Yinqiao powder is 20.16.
In our study, we screened 30 components of Yinqiao powder from the TCMSP database based on OB and DL, and verified 5 components of hesperetin, eriodictyol, luteolin, quercetin, and naringenin by LC-MS analysis.
Luteolin, eriodictyol, quercetin, and naringenin were other effective active ingredients present in Yinqiao powder acting on COVID-19. The hub proteins of Yinqiao powder were IL-6, tumor necrosis factor (TNF), mitogen-activated protein kinase 3 (MAPK3), and tumor protein P53 (TP53). Drug-ingredient-gene target network analysis revealed that drugs such as Jinyinhua, Jingjiesui, Lianqiao, Bohe, Jiegeng, and Gancao have the ability to improve symptoms in COVID-19 patients.
Drug-ingredient-gene target network analysis revealed that Jinyinhua, Lianqiao, Jingjiesui, Jiegeng, Bohe, and Gancao have potential anti-COVID-19 effects.Some of these drugs have been shown to have obvious benefits in improving clinical symptoms in patients with COVID-19.
According to the authors, the mechanisms by which Yinqiao powder may help treat COVID-19 are the TNF signaling pathway, the Toll-like receptor signaling pathway, the T cell receptor signaling pathway, and the MAPK signaling pathway. They believe that this study provides a new perspective for finding potential drugs to treat COVID-19.
Although these signaling pathways have been associated with the development and development of COVID-19, there are currently no experiments to further test the specific role of Yinqiao powder on COVID-19 in these signaling pathways.
Traditional herbal medicines may help treat COVID-19 symptoms
Source link Traditional herbal medicines may help treat COVID-19 symptoms
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