Tucson

UA researchers focus on starving tumors, stunting cancer growth | Local news – Tucson, Arizona

Tucson, Arizona 2021-10-12 17:00:00 –



Dr. Noel Wafel, Associate Professor of Cellular and Molecular Medicine, University of Arizona School of Medicine.


Courtesy Mitchell Pemasirn


By Katya Mendoza for Arizona Daily Star

Researchers at the University of Arizona Cancer Center have discovered new ways to control tumor vascular growth. This is a development that has the potential to facilitate the treatment of cancer patients.

“Tumors need blood vessels to supply the oxygen and nutrients they need to grow,” said former graduate student Andrea Casillas. This process of forming new blood vessels, called angiogenesis, is the way cancer cells spread beyond the primary or early stage tumors.

According to Casillas, Assistant Professor Noel Wafer started the project after studying the role of the provirus insert (PIM1) in the molony mouse leukemia virus, a survival-promoting protein.

In his latest study, Warfel, who specializes in cell and molecular medicine at UA Medical College, found out how tumors containing high levels of PIM1 are resistant to drugs that normally inhibit or block the growth of cancer. Identified. Tumors expressing PIM1 instead showed continuous vascular growth in the tumor.

Simply put, treating cancer cells with drugs that successfully block the dilation of blood vessels stops the blood flow and oxygen needed for growth. This leads to more PIM1, restores blood flow and causes resistance to treatment.

UA researchers focus on starving tumors, stunting cancer growth | Local news Source link UA researchers focus on starving tumors, stunting cancer growth | Local news

Back to top button