Before and after the process, researchers took blood, biopsy tissue, and centrifuges and examined vesicles and other molecular changes in the tissue under a microscope.
They were very careful. Prior to improvised weight training, the rodent leg muscles were filled with fragments of a specific genetic substance known as miR-1, which regulates muscle growth. In normal untrained muscles, miR-1, one of a group of small chains of genetic material known as microRNA, continues to brake muscle building.
However, after the deuterostome resistance exercise, which consisted of walking around, the animal’s leg muscles appeared to be depleted of miR-1. At the same time, the vesicles in their bloodstream are now full, as was the case with nearby adipose tissue. Scientists seem to conclude that animal muscle cells pack microRNA fragments that slow hypertrophy into vesicles and post them to adjacent fat cells, which causes muscle to grow quickly.
But after the arrival of miR-1, scientists wondered what they were doing with fat. To investigate, they marked vesicles from weight-trained mice with fluorescent dye, injected them into untrained animals, and followed the path of glowing bubbles. Scientists saw the fat-laden vesicles and dissolved them to deposit the miR-1 cargo there.
Shortly thereafter, some of the genes in adipocytes became overdriven. These genes help break down fat into fatty acids, which other cells use as fuel to reduce fat accumulation. In effect, weight training reduced fat in mice by creating vesicles in the muscle that signaled that it was time to break down itself into fat via genetic signals.
John J. McCarthy, a professor of physiology at the University of Kentucky and author of the study along with graduate student Ivan J. Vechetti Jr. and other colleagues, said:
But the mouse is not a person. Therefore, as a final aspect of the study, scientists collected blood and tissue from healthy men and women who underwent a single fatigued underweight training and miR-1 levels of volunteer muscle as well as mice. After lifting, the amount of vesicles containing miR-1 in the bloodstream surged.
Of course, this study is primarily aimed at mice and is not designed to tell you how often or how strongly you should lift to maximize vesicle output and fat burning. However, the results still serve as a strong reminder that “muscle mass is crucial to metabolic health” and that each time you gain weight, you increase that amount and start talking to your tissue.
Weightlifting?Your fat cells want to have words
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