Fenbendazole, also known as Panacur or Fenben is an anthelmintic medication in the class of benzimidazole which has been around and available in different parts of the world since 1974.
Fenbendazole has been popularly known to have a measurable amount of anticancer capabilities for many years now. This has resulted in different hypotheses on repackaging this dog expelling medication as an anti-cancer medication. Similarly, medications in the category of benzimidazoles like vinca alkaloids and taxols can be employed for chemotherapeutic purposes. Also, according to available reports on toxicology, humans can tolerate the oral consumption of fenbendazole although there is limited observation in humans.
Normally, fenbendazole is purely available as a powder, less soluble in water and whitish in color.
The reabsorption of the medication in the intestinal tract is very low but consuming it with food in the gut can help enhance its bioavailability.
The working method of fenbendazole
Originally, fenbendazole was developed to destroy parasites through the selective inhibition of the microtubules by combining itself with the β-tubulin. This helps to kill the parasites by polymerizing the tubulin dimers in the parasite’s cells. The fascinating thing is that a similar action against tumor cells might be discovered in benzimidazole group medications such as fenbendazole. As of now, the three techniques used by fenbendazole to eliminate cancer includes:
This anti-cancer capability occurs as a result of the drug’s interaction with the β-tubulin which results in the arrest of cell cycles and cytotoxicity.
There is a good documentation on the polymerizing inhibition of tubulin through the carbonates of benzimidazole in human cancer cells and helminths.
Restriction of the absorption of glucose by tumor cells
Tumor cells are recognized to significantly absorb glucose. When compared with typical cancer cells, tumor cells absorb glucose 200 times quicker as a result of aerobic glycolysis also known as the Warburg effect. Highly radioactive glucose, considered to be the region of inflammation or cancerous tumors can be discovered vividly in PET scans.
Buy Fenbendazole powder inhibits the growth of tumor cells with sugar by inhibiting the absorption of glucose which reduces the level of GLUT transporters (path through which glucose from the blood passes into tumor cells) and the enzyme Hexokinase II. This enzyme helpsto improve the wellbeing of tumor cells by promoting the absorption of glucose and improving the acidosis of lactose in extracellular matrices,
Furthermore, the reactivation of the protein p53 inhibits the production of fuel for tumors. The introduction of p53 helps to restrict the action and expression of GLUT 1 and 4 transporters of the cells.
P53 gene reactivation
There is controversy on this working method and additional research is required to confirm this effect by fenbendazole.
But there is a significant amount of studies that show that fenbendazole can significantly help reduce the effect of cancer in the human body.
A study also revealed that humans have only a single copy of the p53 gene in their genome compared to elephants that have 20 p53 copies. This is the reason humans are more prone to cancer than elephants. Notwithstanding the large body size, the number of cells, and possible genetic mutations of these creatures.
Tumor cells are not resistant to fenbendazole.
Theamazingthingis that tumor cells are unable to resist this dog worm expelling medication or develop resistance to its presence. Sadly, this is also a similar effect to several therapies and chemotherapy medications.
The major working method of chemoresistance is the adaptation of tumor cells in order to eliminate the medication through special drug efflux pumps known as P-glycoproteins. Since tumor does not recognize or target fenbendazole, it is difficult to eliminate the drug once introduced.
So, tumor cells can’t resist fenbendazole as it is a potent killer of tumor cells compared to docetaxel, paclitaxel, vincristine, vinblastine, and other chemotherapy medications.
Cancers can be sensitized by fenbendazole to radiotherapy.
Similar to the sensitization of cancers to radiotherapy by chemotherapy agents, fenbendazole can also sensitize cancers from the taxane group.
Fenbendazole can perform as a slight microtubules destabilizing agent which can result in the death of tumor cells.
To find out more visit: https://www.fenbenlab.com/