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Worrisome coronavirus variant now linked to half of cases in California – Twin Cities

2021-02-23 10:53:54 –

According to data from the new University of California, San Francisco, released Monday, the first identified coronavirus variant in Denmark is now booming in California, accounting for more than half of the 44 county samples.

Scientists have found that this variant, called L452R, is more infectious than the original virus strain, but is unlikely to spread more rapidly than the British variant.

Also, new evidence linking this variant to an increased risk of severe illness and death is plagued. In addition, vaccinated people appear to produce less protective antibody in response to the mutant, suggesting that it may evade our immune defenses.

This raises concerns that it can cause a pandemic, cause more deaths, and reduce the effectiveness of the vaccine.

Dr. Charles Chiu of the University of California, San Francisco concludes that the strain “should be designated as a variant of concern and requires urgent follow-up.” His lab is working with the state public health service to look for cases of new variants.

Even if the state’s COVID-19 cases decline, “this highlights the need for us to monitor it … how important it becomes and how it reacts to the vaccine. To understand what it is, the non-profit Chan Zuckerberg Biohub in San Francisco is making a major effort to enhance the gene sequence of the COVID-19 virus throughout California.

“It’s not time to relax our vigilance,” he said.

The subspecies, which Chiu’s lab estimates emerged in California last May, has increased prevalence from 0% of sample cases in early September 2020 to more than 50% by the end of January 2021. Did.Kaiser Permanente San Jose’s homes, prisons and emergency departments have staff Inflatable Christmas tree costumes can infect at least 90 people..

New insights from a study in San Francisco’s Mission District, also published Monday, scrutinize the behavior of the virus.

The team found that 53% of all positive test samples collected at the 24th Street Mission BART station in San Francisco’s predominantly Latin community between January 10 and January 27 were variants. .. This is a significant increase from November, when only 16% of positives were included. Tested by Dr. Diane Havlir, an infectious disease expert at the University of California, San Francisco.

The mission district survey was conducted by Unidos en Salud, a volunteer-led collaboration between the University of California, San Francisco, the Chanzuckerberg Biohub (CZ Biohub), the Chanzuckerberg Initiative, and the Latin American Task Force of COVID-19. It was. With the help of the community, scientists were able to investigate important questions about home infections. Compared to the original virus, the L452R variant is a bit more aggressive, with a “secondary attack rate” increasing from 25% to 35% and spreading more quickly in the home.

Evidence of increased infectivity was also found by Chiu’s study. In his laboratory, it was detected that when the virus was released into the environment, it propagated faster and increased the “excretion” of the virus. We also found that when introduced into cells and tissues grown in the laboratory, the mutants became more infectious.

The proportional increase in state-wide cases due to variants was rapid, doubling every 18 days. Subspecies-related cases doubled every 14 days in Santa Clara County and every 33 days in Alameda County.

To test whether the antibody could dodge this new strain, Chiu’s team worked in the laboratory against antibodies from people who were not this strain but were vaccinated or already infected with the virus. I tested the cultured virus. They found that the ability of antibodies to dodge mutant viruses was reduced by a factor of two to four. This means that the vaccine may need to be restructured to maintain its effectiveness.

Need an updated “booster” vaccine? No one knows yet, but Haveril called it a “certain possibility.”

To find out if the mutant caused a more serious illness, Chiu’s team studied medical records of patients admitted to treatment with UCSF. After controlling age, gender, and ethnicity, we found that people infected with the subspecies were significantly more likely to be admitted to the intensive care unit and die.

The L452R variant was first detected in some isolated cases in Denmark last March and appeared in California as early as May, but was not discovered until summer and autumn. There are four mutations in the genetic code of the spiked protein that the virus uses to invade cells. Therefore, it is highly infectious, easy to infect, and easy to spread.

Worrisome coronavirus variant now linked to half of cases in California – Twin Cities Source link Worrisome coronavirus variant now linked to half of cases in California – Twin Cities

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